We recently showed that the gut microbiota composition of stunted children was different from that of children with normal nutritional status. Here, we compared immune status and fecal microbial metabolite concentrations between stunted and normal children, and we correlated macronutrient intake (including energy), metabolites and immune status to microbiota composition. The results show that macronutrient intake was lower in stunted children for all components, but after correction for multiple comparison significant only for energy and fat. Only TGF-β was significantly different between stunted children and children of normal nutritional status after correction for multiple comparisons. TNF-alpha, IL-10, lipopolysaccharide binding protein in serum and secretory IgA in feces were not significantly different. Strikingly, all the individual short-chain and branched-chain fatty acids were higher in fecal samples of stunted children (significant for acetate, valerate and total SCFA). These metabolites correlated with a number of different microbial taxa, but due to extensive cross-feeding between microbes, did not show a specific pattern. However, the energy-loss due to higher excretion in stunted children of these metabolites, which can be used as substrate for the host, is striking. Several microbial taxa also correlated to the intake of macronutrients (including dietary fibre) and energy. Eisenbergiella positively correlated with all macronutrients, while an uncharacterized genus within the Succinivibrionaceae family negatively correlated with all macronutrients. These, and the other correlations observed, may provide indication on how to modulate the gut microbiota of stunted children such that their growth lag can be corrected. Trail registered at https://clinicaltrials.gov/ct2/show/NCT04698759.
COVID-19 is an infectious disease in humans. This disease is caused by a new virus similar to SARS-CoV, called SARS-CoV-2. This virus attacks the human respiratory system and causes symptoms such as cough, fever above 38°C, shortness of breath, muscle aches, malaise, and diarrhea. Elevated levels of D-Dimer are often found in patients with severe COVID-19 symptoms. Previous studies have shown that increased levels of D-Dimer can increase the risk of death and is also a marker of poor prognosis. The purpose of this study was to provide an overview of D-Dimer levels in patients confirmed by COVID-19 with moderate and severe symptoms at UKI General Hospital. This study is a cross-sectional study with descriptive and analytic data presentation from the Medical Record document of UKI General Hospital. Data that has been collected was processed using the Mann-Whitney test. The subjects of this study are 211 patients who were confirmed to have COVID-19 through RT-PCR examination and had checked for D-Dimer levels. The Mann-Whitney test that was carried out gave a p-value <0.05, which means a significant difference in the mean D-Dimer level between COVID-19 patients with moderate and severe symptoms. The average level of D-Dimer in moderate symptoms was 441.272 ng/mL with 154 patients. The average level of D-Dimer in severe symptoms is 1,231,630 ng/mL with 57 patients. Key words: D-Dimer, COVID-19, mild symptoms, severe symptoms.
Coronavirus Disease 2019 (COVID-19) is a disease caused by SARS-CoV-2 and has caused a global pandemic. Patients with COVID-19 can experience symptoms such as fever, dry cough, headache, and shortness of breath which can lead to pneumonia. Excessive inflammation is considered a leading cause of critical illness and death in COVID-19 patients. C-Reactive Protein is a sensitive indicator as an early marker of infection and inflammation. This study presents an overview of the difference in the average CRP levels between patients with moderate and severe confirmed COVID-19 symptoms at UKI Hospital for June-September 2021. The study design was cross-sectional with descriptive and analytical data presentation obtained from medical record documents at UKI Hospital. The average CRP level of COVID-19 patients with moderate symptoms is 63,705 mg/L, totaling 139 patients. The average CRP level of COVID-19 patients with severe symptoms is 132,050 mg/L, totaling 57 patients. The results obtained from the Mann-Whitney test between groups of patients with moderate and severe COVID-19 showed a significant difference between CRP levels with moderate and severe symptoms with p <0.05. Keywords: COVID-19, CRP levels, SARS-CoV-2
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.