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Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brainstem structures responsible for cardiovascular control. Therefore, to investigate this possibility the present study verified the effects of CBD (15, 30 and 60 nmol) injected into the cisterna magna on the autonomic and behavioral changes induced by acute restraint stress. During exposure to restraint stress (1h) there was a significant increase in mean arterial pressure (MAP) and heart rate (HR). Also, 24h later the animals showed a decreased percentage of entries onto the open arms of the elevated plus-maze. These effects were attenuated by CBD (30 nmol). The drug had no effect on MAP and HR baseline values. These results indicate that intracisternal administration of CBD can attenuate autonomic responses to stress. However, since CBD decreased the anxiogenic consequences of restraint stress, it is possible that the drug is also acting on forebrain structures.

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Objetivo: Relatar as experiências de trabalho remoto e EaD de um grupo do PET-Saúde Interprofissionalidade na pandemia. Método: Trata-se de um relato de experiência das atividades realizadas por um grupo do PET-Saúde, vinculado a Universidade Estadual de Feira de Santana (UEFS) e ao Centro de Atendimento ao Diabético e Hipertenso (CADH), de março a junho de 2020. As atividades presenciais na UEFS e no CADH foram substituídas por atividades remotas e EaD. A metodologia utilizada envolveu a incorporação de ferramentas virtuais em: 1) Seminários e cursos EaD; 2) Estabelecimento de estratégias de inovação para atuação em saúde; 3) Construção de materiais de Educação em Saúde. Resultados: As ferramentas educacionais virtuais permitiram a realização de um trabalho inovador, focado na formação inicial e continuada de alunos, professores e profissionais de saúde. Mudanças no fluxo dos pacientes, produção de cartilha e artigos também foram atividades desenvolvidas. Conclusão: O uso de plataformas virtuais e EaD favoreceram o planejamento de ações, proporcionando ganho de conhecimento individual e coletivo, permitindo alterações no serviço, orientação dos pacientes e produção científica.

The ventral portion of the medial prefrontal cortex comprises the prelimbic cortex (PL) and the infralimbic cortex (IL). Several studies have indicated that both the PL and the IL play an important role in cardiovascular control. Chemoreflex activation by systemic administration of potassium cyanide (KCN) evokes pressor and bradycardiac responses in conscious rats, in addition to an increase in respiratory frequency. We report here a comparison between the effects of pharmacological inhibition of PL and IL neurotransmission on blood pressure and heart rate responses evoked by chemoreflex activation using KCN (i.v.) in conscious rats. Bilateral microinjection of 200 nl of the unspecific synaptic blocker CoCl 2 (1 mm) into the PL evoked a significant attenuation of the pressor response, without affecting the chemoreflex-induced heart rate decrease. However, IL local synapse inhibition evoked no changes in cardiovascular responses induced by chemoreflex activation. Thus, our results suggest that the pressor but not the bradycardiac response to chemoreflex activation is, at least in part, mediated by local neurotransmission present in the PL cortex, without influence of the IL cortex.