Objective: Polycystic ovary syndrome (PCOS) is a condition of anovulation causing infertility. Many kinds of therapy have been used to treat PCOS. However, the results have not been satisfactory. Acupuncture is a trusted way to repair the reproductive system. Yet, there is not enough evidence of the effectiveness of acupuncture to induce ovulation or to treat infertility in patients who have PCOS. The objectives of this study were to find out how successfully electroacupuncture (EA) could complete conventional therapy for patients with PCOS-related infertility, to analyze the effect of EA on these patients, and if EA could repair folliculogenesis to create quality oocytes so that these patients could become pregnant.
Background: Infertility increases annually, by 0.370% in women and 0.291% in men. One of the causes of male infertility is idiopathic in the form of cigarettes, alcohol, drugs, obesity, psychological stress, old age, dietary factors, and exposure to toxins in the environment or work. These factors can cause oxidative stress that can lead to sperm DNA damage or sperm DNA fragmentation as measured through the DNA Fragmentation Index (DFI). So this study to analyzed about the relationship between smoking, age, Body Mass Index, and abstinence period with DNA Fragmentation Index in infertile patient. Subjects and Method: This type of research is observational analytics with a cross-sectional approach. The study was conducted at the Sekar Clinic of Dr. Moewardi Hospital Surakarta. A total of 35 subjects of male infertility patients performed DNA examinations of sperm fragmentation. Independent variables: smoking, age, body mass index (BMI), and abstinence. Dependent variable: DFI. Data is collected using medical records and analyzed using SPSS applications through univariate, bivariate, and multivariate analysis (logistic regression). Results: Smoking (OR= 0.68; 95% CI= 0.52 to 2.23; p= 0.636), age (OR= 17.33; 95% CI=31.06 to 35.05; p= 0.003), BMI (OR= 1.47; 95% CI= 24.20 to 26.52; p = 0.58), abstinence (OR= 5.67, 95% CI =3.76 to 4.69; p=0.02). Results of multivariate analysis with logistic regression at age (OR= 13.62; 95% CI =1.42 to 130.60; p=0.024), and abstinence (OR= 3.94; 95% CI= 0.84 to 21.58; p= 0.114). Conclusion:There is a relationship between age and abstinence to DFI. There is no relationship between smoking and BMI against DFI.
Background<br />The polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.<br /><br />Methods<br />This cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. <br /><br />Results<br />Mean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. <br /><br />Conclusion<br />Expression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.
Latar belakang: Endometriosis merupakan salah satu gangguan ginekologis berkaitan hormon estrogen dan berkembang melalui mekanisme peradangan. Pola distribusi jaringan lemak memiliki kaitan dengan hormon estrogen dan peningkatan masa jaringan lemak dapat mempengaruhi sistem pertahanan tubuh. Penelitian ini bermaksud untuk mempelajari hubungan antara keberadaan jaringan lemak berlebih pada regio tertentu dengan endometriosis. Metode Penelitian: Studi observasi potong lintang dilakukan pada pasien tindakan pembedahan pada poli obstetri dan ginekologi RSUD Dr. Moewardi dan RS UNS. Sebanyak 87 pasien dibagi menjadi kelompok normal, obesitas sentral, dan obesitas perifer berdasarkan hasil pengukuran indikator antropometri serta dilakukan pendataan konfirmasi endometriosis menurut hasil lab patologi anatomi. Data kemudian dianalisis dengan menggunakan uji kai kuadrat Pearson. Hasil Peneltian: Subjek pada kelompok endometriosis berusia lebih muda dibandingkan kelompok non endometriosis (p < 0,05). Tidak ada perbedaan berat badan, tinggi badan, dan indeks massa tubuh diantara dua kelompok (p > 0,05). Dismenorrhea dibuktikan berhubungan dengan endometriosis (p > 0,05), namun hubungan tidak ditemukan antara endometriosis dengan infertilitas. Analisis statistik tidak menunjukkan adanya hubungan yang signifikan secara statistik antara obesitas menurut pola distribusi lemak tubuh dengan kejadian endometriosis. Simpulan Penelitian: Obesitas menurut pola distribusi lemak tubuh tidak berhubungan dengan kejadian endometriosis. Kata Kunci: endometriosis; adipositas; obesitas; pola distribusi lemak
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