Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is pervasively overexpressed and correlated with tumor invasion, progression, metastasis, and poor prognosis in various human cancers including breast cancer (BC) that plays a role as an oncogenic molecule. A common functional single-nucleotide polymorphism (SNP) (rs12826786 C>T) at the HOTAIR promoter has been reported to influence HOTAIR expression and gastric adenocarcinoma susceptibility, but relation of HOTAIR rs12826786 C>T polymorphism with BC susceptibility and clinicopathological characteristics has yet to be reported. To explore the association of the HOTAIR rs12826786 C>T polymorphism with the risk of BC in a Turkish population, a hospital-based case-control study was carried out consisting of 123 BC patients and 122 age-matched healthy controls. HOTAIR rs12826786 C>T polymorphism was determined by real-time polymerase chain reaction (PCR) using TaqMan assay. We found that women carrying TT genotype of HOTAIR rs12826786 C>T polymorphism had an increased risk of developing BC in both codominant (odds ratio (OR) = 2.24, 95 % confidence interval (CI) 1.05-4.81, P = 0.02) and recessive (OR = 2.49, 95 % CI 1.25-4.97, P = 0.008) inheritance models. Moreover, TT genotype of HOTAIR rs12826786 C>T polymorphism was significantly related with multiple clinicopathological characteristics concerned with worse BC progression such as advanced TNM stage (III and IV), larger tumor size (T3 and T4), and distant metastasis (M1), as well as poor histological grade (III) (P < 0.05). Because of our results put forward for the first time that TT genotype of HOTAIR rs12826786 C>T polymorphism might play crucial roles in genetic susceptibility and poor prognosis for BC in Turkish population, further independent studies are needed to confirm our results in a larger series, as well as in patients of distinct populations.

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Our results demonstrate that the HOTAIR rs12826786 C>T polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.

Overexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with tumorigenesis and multiple cancer types including lung cancer. In this study, the association between two HOTAIR single nucleotide polymorphisms (SNPs) (rs12826786 and rs1899663) on the risk and clinical characteristics of lung cancer in a Turkish population was investigated. We genotyped HOTAIR rs12826786 and rs1899663 polymorphisms in 180 Turkish people including 87 lung cancer patients (71 males and 16 females) and 93 age-matched healthy controls (67 males and 26 females) by a TaqMan real-time polymerase chain reaction method. The mean age value of the lung cancer patients and control subjects were 59.27 ± 10.55 and 61.77 ± 12.00, respectively. We found that none of the two HOTAIR polymorphisms (rs12826786 T>C, rs1899663A>C) has any significant association with the increased risk of lung cancer in any type of inheritance genetic models. However, our research indicated that carriers of Trs12826786/Crs1899663 (ht3) (P = 0.03) had an increased risk of lung cancer susceptibility.

Amaç: Bu çalışmada bronşektazili hastaların klinik özellikleri belirlendi ve cerrahinin uzun dönem sonuçları değerlendirildi. Ça lış ma pla nı: Ocak 2001 -Haziran 2011 tarihleri arasında, İstanbul Üniversitesi İstanbul Tıp Fakültesi Göğüs Cerrahisi Kliniği'nde cerrahi rezeksiyon uygulanan 39 (23 erkek, 16 kadın; ort. yaş 25.6 yıl; dağılım 5-63 yıl) bronşektazi hastasının tıbbi kayıtları retrospektif olarak incelendi. Uzun dönem sonuçlar için hastalara mektup, telefon veya poliklinik kontrolleri ile ulaşıldı. Hastalar yaş, cinsiyet, etyolojik faktörler, semptomlar, tanı yöntemleri, lezyonun yerleşim yeri, yapılan ameliyat, morbidite, hastanede kalış süresi ve uzun dönem sonuçlar açısından değerlendirildi. Bul gu lar: En sık görülen semptom öksürük ve balgam çıkarma, en sık etyolojik faktör çocukluk çağından bu yana geçirilen enfeksiyonlar idi. Yirmi iki hastada (%56) sol akciğer tutulumu, 11 hastada (%28) sağ akciğer tutulumu ve altı hastada (%15) iki taraflı akciğer tutulumu vardı. On altı hastada (%41) birden çok lob tutulumu ve 23 hastada (%59) tek lob tutulumu vardı. Bronşektazinin en sık etkilediği alan, 13 hasta (%33) ile sol alt lob idi. Otuz bir hastada (%80) tam rezeksiyon, sekiz hastada (%20) tam olmayan rezeksiyon uygulandı. Uzun dönem sonuçlarına ulaşılabilen 33 hastadan 22'sinde (%67) tam şifa, dokuzunda (%27) klinik semptomlarda iyileşme ve ikisinde (%6) başarısızlık saptandı. Tam şifa ve kısmi şifa oranları, tam rezeksiyon uygulanan hastalarda sırası ile %73 ve %23 iken, tam olmayan rezeksiyon uygulanan hastalarda sırası ile %43 ve %43 olarak saptandı. So nuç:Bronşektazi hastalarında cerrahi tedavi %90'ın üzerinde başarı oranı ile iyi bir tedavi seçeneğidir. Tam rezeksiyon daha iyi uzun dönem sonuçlara sahiptir. Ancak tam rezeksiyon için uygun olmayan hastalarda tam olmayan rezeksiyon yapılabilir.Anah tar söz cük ler: Bronşektazi; uzun dönem sonuç; cerrahi rezeksiyon. Background:This study aims to determine the clinical characteristics of the patients with bronchiectasis and evaluate the long-term outcomes of surgery. Methods: Medical records of 39 patients (23 males and 16 females; mean age 25.6 years; range, 5 to 63 years) with bronchiectasis who underwent surgical resection at were retrospectively reviewed. Long-term follow-up data of the patients were obtained by the letter, telephone or outpatient control visits. Patients were evaluated according to the age, sex, etiological factors, symptoms, diagnostic methods, localization of lesion, surgery performed, morbidity, duration of hospital stay and long-term outcomes. Results:The most frequent symptoms were cough and sputum, while the most frequent etiological factor was having infections since childhood era. Twenty-two patients (56%) had left lung involvement, 11 patients (28%) had right lung involvement, and six patients (15%) had bilateral lung involvement. There were multiple lobe involvement in 16 patients (41%) and single lobe involvement in 23 patients (59%). The most affected region by bronchiectasis was the left lower lobe in 13 patients ...

An isolated renal cyst hydatic in a 65 year old man with unusual symptomatology, course and complications were presented.

Bu çalışmada, bronşiyal karsinoid tümörlü hastalarda cerrahi tedavi, ameliyat sonrası komplikasyonlar ve uzun dönem sonuçlar sunuldu. Ça lış mapla nı:Ocak 2000-Aralık 2010 tarihleri arasında ameliyat öncesi ve sonrası patolojik olarak bronşiyal karsinoid tümör olduğu doğrulanmış 57 hastaya (34 kadın, 23 erkek; ort. yaş 43 yıl; dağılım 13-83 yıl) akciğer rezeksiyonu uygulandı. Cerrahi tipi, karsinoid tümörün histopatolojik tipi, ameliyat sonrası komplikasyonlar ve uzun dönem sonuçlar değerlendirildi. Bul gu lar: Patolojik muayenede 44 (%77) tipik, 13 (%23) atipik karsinoid tümör saptandı. Hastaların 23'üne (%40.3) bronşiyal sleeve reseksiyon, üçüne (%5.2) pnömonektomi, 27'sine (%47.3) lobektomi, dördüne (%7) sublobar rezeksiyon uygulandı. Sekiz hastada (%14) ameliyat sonrası komplikasyon gözlendi. Ameliyat sırası mortalite gözlenmedi. Takip döneminde hiçbir hastada ölüm ve lokal nüks olmadı. So nuç: Parenkim koruyucu rezeksiyonlar (sleev lobektomi ve sleev bronşiyal rezeksiyon), tipik karsinoid tümörlü hastalarda, negatif cerrahi sınır elde etmek koşulu ile uzun dönem takip sürecinde iyi prognoz sağlayabilir. Anah tar söz cük ler: Bronşiyal karsinoid tümör; uzun dönem sonuç; parenkim koruyucu rezeksiyon. Background:This study aims to present surgical treatment, postoperative complications, and long-term outcomes in patients with a bronchial carcinoid tumor. Methods: Between January 2000 and December 2010, 57 patients (34 females, 23 males; mean age 43 years; range 13 to 83 years) underwent pulmonary resection for pre-and postoperatively pathologically confirmed bronchial carcinoid tumors. Type of surgery, histopathological types of carcinoid tumor, postoperative complications, and long-term results were evaluated. Results: Pathological examination revealed 44 (77%) typical and 13 (23%) atypical carcinoid tumors. Bronchial sleeve resection, pneumonectomy, lobectomy and sublobar resection were performed on 23 (40.3%), three (5.2%), 27 (47.3%) and four patients (7%), respectively. Eight patients (14%) had postoperative complications. There was no perioperative mortality. During the follow-up period, no mortality or local recurrence occurred. Conclusion: During long-term follow-up period, parenchyma-sparing resections (sleeve lobectomy and bronchial sleeve resection) can achieve good prognosis in patients with typical carcinoid tumor if tumor free surgical margins can be obtained.