Polymorphisms in human telomerase reverse transcriptase (h TERT ) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case–control study

Bayram, Süleyman; Ülger, Yakup; Sümbül, Ahmet Taner; Kaya, Berrin Yalınbaş; Genç, Ahmet; Rencüzoğulları, Eyyüp; Dadaş, Erdoğan

doi:10.1016/j.gene.2016.03.030

Cited by 20 publications

(20 citation statements)

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“…However, Jannuzzi et al [23] reported that there was no correlation between TERT 2736100 polymorphism and susceptibility to hepatocellular carcinoma. Our study is the second study focused on the association between TERT gene and GC risk, and we concluded similar results with Bayram et al [21] on relationship between rs2736100 polymorphism and GC.…”

Section: Discussionsupporting

confidence: 91%

“…Lan et al [22] suggested that G allele and/or GG genotype of TERT 2736100 T>G polymorphism was significantly associated with an increased risk of LC susceptibility. The findings obtained by Bayram et al [21] also support previous data showing that there was an association between the G allele and/or GG genotype of TERT rs2736109 G>A polymorphism and increased risk for human cancers. However, Jannuzzi et al [23] reported that there was no correlation between TERT 2736100 polymorphism and susceptibility to hepatocellular carcinoma.…”

Section: Discussionsupporting

confidence: 79%

“…In addition, in these previous studies, few studies reported the impact of gene- gene interaction among several SNPs and gene—environment risk factors interaction on GC risk. Till now, just one study conducted by Bayram et al [21] focused on the association between TERT gene and GC risk. They found for the first time that TERT rs2736109 G>A, rs2735940 T>C and rs2736100 T>G polymorphisms were associated with the risk of GC susceptibility, but they did not find association between rs2853669 and GC risk.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Zhang

Gao

et al. 2017

Oncotarget

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AimsTo investigate the association of telomerase reverse transcriptase (TERT) gene polymorphisms and additional gene-gene and gene- environment interaction with gastric cancer (GC) risk.ResultsGC risk was significantly higher in carriers of G allele of rs2736100 than those with TT genotype (TG+ GG versus TT), adjusted OR (95%CI) =1.68 (1.26-2.17), and higher in carriers of G allele of rs2853669 than those with AA genotype (AG+ GG versus AA), adjusted OR (95%CI) = 1.72 (1.19-2.33). We also found that interaction between rs2736100 and smoking was associated with higher GC risk. Smokers with TG or GG of rs2736100 genotype have elevated GC risk, compared to never- smokers with TT of rs2736100 genotype, OR (95%CI) = 3.12 (1.82 -4.61). Pairwise linkage equilibrium (LD) analysis between SNPs was measured and the D’ value between rs2736100 and rs2736109 was more than 0.8. A haplotype containing the rs2736100- G and rs2736109- A alleles was associated with a statistically increased GC risk (OR= 2.66, 95%CI= 1.28 – 4.12, p<0.0001).Materials and MethodsA total of 1088 participants (686 males, 402 females) were selected, including 360 GC patients and 728 normal participants. Logistic regression was performed to investigate association between single nucleotide polymorphisms (SNPs) within TERT gene and GC susceptibility. Generalized multifactor dimensionality reduction (GMDR) model was used to screen gene- gene and gene- environment interaction combinations.ConclusionsWe found that G allele of rs2736100 and G allele of rs2853669 in TERT gene, interaction between rs2736100 and smoking, and haplotype containing the rs2736100- G and rs2736109- A alleles were all associated with increased GC risk.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Zhang

Gao

et al. 2017

Oncotarget

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“…In most of the included studies, the TERT rs2736100 polymorphism genotypic distribution followed Hardy-Weinberg equilibrium (HWE) in controls, except for seven studies [6, 28, 43, 51, 63, 66, 72]. Since the genotype distributions of other polymorphisms were in compliance with HWE in these seven studies, we included these studies in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis

Mao³

et al. 2017

Oncotarget

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Abnormal telomerase activity is implicated in cancer initiation and development. The rs2736100 T > G polymorphism in the telomerase reverse transcriptase (TERT) gene, which encodes the telomerase catalytic subunit, has been associated with increased cancer risk. We conducted a meta-analysis to more precisely assess this association. After a comprehensive literature search of the PubMed and EMBASE databases up to November 1, 2016, 61 articles with 72 studies comprising 108,248 cases and 161,472 controls were included in our meta-analysis. Studies were conducted on various cancer types. The TERT rs2736100 polymorphism was associated with increased overall cancer risk in five genetic models [homozygous model (GG vs. TT): odds ratio (OR) = 1.39, 95% confidence interval (95% CI) = 1.26-1.54, P < 0.001; heterozygous model (TG vs. TT): OR = 1.16, 95% CI = 1.11-1.23, P < 0.001; dominant model (TG + GG vs. TT): OR = 1.23, 95% CI = 1.15-1.31, P < 0.001; recessive model (GG vs. TG + TT): OR = 1.25, 95% CI = 1.16-1.35, P < 0.001; and allele contrast model (G vs. T): OR = 1.17, 95% CI = 1.12-1.23, P < 0.001]. A stratified analysis based on cancer type associated the polymorphism with elevated risk of thyroid cancer, bladder cancer, lung cancer, glioma, myeloproliferative neoplasms, and acute myeloid leukemia. Our results confirm that the TERT rs2736100 polymorphism confers increased overall cancer risk.

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“…The different variants of genetic polymorphisms in this gene have been associated with differences in TL and with the prognosis of patients in several tumor models, including lung, gastric, breast and kidney cancer. [42][43][44][45] As so, TL is also another widely discussed biomarker since it has been widely associated with innumerous diseases, environmental exposures and phenotypic characteristics. 10,40,46 There are several methods to determine the TL in tissues, single cells and DNA preparations.…”

Section: Telomeres As Biomarkers In Cancermentioning

confidence: 99%

<p>Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney</p>

Morais¹,

Dias²,

Teixeira³

et al. 2020

CMAR

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Renal cell carcinoma (RCC) is a heterogeneous group of cancers where the clear cell (ccRCC) is the most common and the most lethal. The absence of accurate diagnostic and follow-up biomarkers along with the time-limited response to therapies may explain the lethality and shows the necessity of new sensitive and specific biomarkers. One of the most studied molecules are the telomeres: specialized ribonucleoprotein structures that keep the structural integrity of the genome. Among other features, telomere length (TL) has been widely studied in several tumor models regarding its biomarker potential, due to the easy detection and quantification. The scope of this review was to analyze all the information about this parameter in RCC. There was some disparity in the results of the studies, since some pointed to an association between short TL and risk or poor outcome of RCC; others between long TL and RCC outcome and some did not find any association. We propose some epidemiological and biological explanations to these differences. The telomeres may play a dual role during RCC carcinogenesis in the early stages, short telomeres may increase RCC risk and in late carcinogenesis, long telomeres seem to be associated with tumor prognosis. However, the controversy of the results along with the lack of specificity are some problems that need to be clarified for the usage of TL as a prognostic biomarker.

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Polymorphisms in human telomerase reverse transcriptase (h TERT ) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case–control study

Cited by 20 publications

References 46 publications

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis

<p>Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney</p>

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