In conclusion, a significant relationship was found between decreased serum prolidase activity and keratoconus but there was no significant relationship between keratoconus and serum TAC or TOS.
BackgroundHypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension.Material/MethodsIncluded in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA.ResultsThere were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.ConclusionsWe suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.
Sulfonylurea receptor 1 (SUR1) geni SUR1 proteinini kodlayarak glukozla indüklenen insülin sekresyonunda anahtar rolü oynar. Bu çalışmanın amacı, SUR1 geninin 31. ekzonundaki polimorfizm ile Tip 2 diyabet arasındaki ilişkiyi ve diyabetik hastalardaki obezite ile beraberliğini araştırmaktır. Gereç ve yöntem: Diyabet polikliniğinde takip edilen 90 hasta (45 kadın, 45 erkek) çalışmaya dahil edildi. Serumda glukoz, trigliserid, kolesterol ve tam kanda HbA1c değerleri belirlendi. 31. Egzondaki SNP'ler ise polymeraz zincir reaksiyon / restriksiyon fragment uzunluk polymorphism (PCR-RFLP) yöntemiyle belirlendi. Bulgular: Kontrol grubu ile karşılaştırıldığında Tip 2 diyabetik hastalarda A allel frekansının artmış olduğu gözlendi (%41 ve %24, p<0.01), ve bu ilişkinin obez alt grupta daha belirgin olduğu gözlendi (A allele %44, p<0.01). Hasta ve kontrol grubu arasında 31. Ekzonun R1273R tek nükleotit polimorfiziminde genotip dağılımında obez alt grupta daha fazla olmak üzere (p=0.007) anlamlı fark bulundu (p=0.01). Sonuç: SUR1 geninin 31. Ekzonundaki tek nükleotit polimorfizminin Türk tip 2 diyabet hastalarında ve obez alt grupta önemli rol aldığı söylenebilir.
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