Objective: Inflammation is body reactions in response to tissue injury and infection. In 2011, non-steroidal anti-inflammatory drug (NSAID) was thehighest demand drug in Indonesia. However, long-term treatment using NSAID can cause several side effects to cardiovascular and digestive system.This research aimed to investigate anti-inflammatory properties of binahong leaves (Anredera cordifolia) and pegagan herbs (Centella asiatica).Methods: Ethyl alcohol extract of A. cordifolia leaves and C. asiatica herbs was evaluated for its anti-inflammatory properties using human redblood cell (RBC) – membrane stabilization assay. The extract concentrations used in this study was 100, 200, 400, and 800-ppm, and apigenin andasiaticoside concentration were 1, 2, 3, 4, 5, 6, 10, and 100 ppm. Diclofenac natrium (DN) was used as a standard drug.Results: The results showed that A. cordifolia extract (ACE) alone, C. asiatica extract (CAE) alone, and the combination of ACE and CAE could inhibit thehemolysis of RBC in hypotonic solution. The optimum concentration for ACE alone was 100 ppm; for CAE alone was 400 ppm; and for the combinationof ACE and CAE was 50 ppm and 50 ppm, respectively. Apigenin and asiaticoside in concentration of 1-10 ppm showed more than 97% inhibition ofhemolysis. DN as a standard drug showed optimum inhibition at concentration of 400 ppm.Conclusion: The ethyl alcohol extract of A. cordifolia leaves and C. asiatica herbs showed anti-inflammatory activity, both as a single treatment or ascombinations, and apigenin and asiaticoside were responsible for anti-inflammatory activity in C. asiatica.Keywords: Anti-inflammation, Human red blood cell – membrane stabilization, Anredera cordifolia, Centella asiatica.
Abstrak: COVID-19 merupakan penyakit yang dapat menular sehingga penting nya upaya untuk menekan angka kejadian . Berbagai upaya dilakukan salah satunya yaitu dilaksanakan program vaksinasi dengan tujuan dapat bekerja secara efektif dengan menghasilkan antibodi spesifik pada tubuh sehingga dapat menurunkan risiko kejadian dan memutus rantai penularan. Sikap masyarakat terhadap kesediaan diri untuk melaksanakan vaksinasi masih menimbulkan pro dan kontra. Pada 04 November 2021 tercatat Kabupaten Tasikmalaya menempati urutan petama sebagai wilayah paling rendah angka vaksinasi nya di Jawa Barat. Penelitian dilakukan bertujuan untuk menganalisis apakah terdapat hubungan yang signifikan antara tingkat pengetahuan masyarakat terhadap kesediaan diri untuk vaksin COVID-19 di daerah RW 01 , Kecamatan Cineam, Kabupaten Tasikmalaya. Penelitian yang dilakukan termasuk kedalam jenis penelitian kuantitatif dengan metode observasional analitik dengan pendekatan cross sectional. Pengambilan data dilakukan dengan menyebarkan kuesioner dan didapatkan sampel berjumlah 338 responden. Data dianalisis menggunakan SPSS untuk uji frekuensi dan uji kolerasi dengan Rank Spearman. Hasil yang didapatkan untuk Tingkat pengetahuan masyarakat sebesar 88,9% dan Kesediaan diri sebesar 67,8%, dan uji kolerasi yang didapat yaitu nilai signifikansi 0,000 (0,000<0,05) menunjukan adanya hubungan yang signifikan antara tingkat pengetahuan terhadap kesediaan diri untuk melakukan vaksinasi.
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