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In this paper, a channel coding approach called diversity coding is introduced for self-healing and fault-tolerance in digital communication networks for nearly instantaneous recovery from link failures. To achieve this goal, the problem of link failures is treated as an erasure channel problem. Implementation details of this technique in existing and future communication networks are discussed.

Toxicogenomic analysis of five environmental chemicals was performed to investigate the ability of genomics to predict toxicity, categorize chemicals, and elucidate mechanisms of toxicity. Three triazole antifungals (myclobutanil, propiconazole, and triadimefon) and two perfluorinated chemicals [perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS)] were administered daily via oral gavage for one, three, or five consecutive days to male Sprague-Dawley rats at single doses of 300, 300, 175, 20, or 10 mg/kg/day, respectively. Clinical chemistry, hematology, and histopathology were measured at all time points. Gene expression profiling of livers from three rats per treatment group at all time points was performed on the CodeLink Uniset Rat I Expression array. Data were analyzed in the context of a large reference toxicogenomic database containing gene expression profiles for over 630 chemicals. Genomic signatures predicting hepatomegaly and hepatic injury preceded those results for all five chemicals, and further analysis segregated chemicals into two distinct classes. The triazoles caused similar gene expression changes as other azole antifungals, particularly the induction of pregnane X receptor (PXR)-regulated xenobiotic metabolism and oxidative stress genes. In contrast, PFOA and PFOS exhibited peroxisome proliferator-activated receptor alpha agonist-like effects on genes associated with fatty acid homeostasis. PFOA and PFOS also resulted in downregulation of cholesterol biosynthesis genes, matching an in vivo decrease in serum cholesterol, and perturbation of thyroid hormone metabolism genes matched by serum thyroid hormone depletion in vivo. The concordance of in vivo observations and gene expression findings demonstrated the ability of genomics to accurately categorize chemicals, identify toxic mechanisms of action, and predict subsequent pathological responses.

The interleaver design criteria described in [1] should take into account all error patterns of interest.In [1], let S be the number of streams employed and let α s be the number of times the stream s is employed with a corresponding channel bit equal to 1 in an error path. Then, the interleaver design criteria for single-carrier systems at the beginning of Section II of [1] should be as follows

Sphere decoding (SD) is a low complexity maximum likelihood (ML) detection algorithm, which has been adapted for different linear channels in digital communications. The complexity of the SD has been shown to be exponential in some cases, and polynomial in others and under certain assumptions. The sphere radius and the number of nodes visited throughout the tree traversal search are the decisive factors for the complexity of the algorithm. The radius problem has been addressed and treated widely in the literature. In this paper, we propose a new structure for SD, which drastically reduces the overall complexity. The complexity is measured in terms of the floating point operations per second (FLOPS) and the number of nodes visited throughout the algorithm's tree search. This reduction in the complexity is due to the ability of decoding the real and imaginary parts of each jointly detected symbol independently of each other, making use of the new lattice representation. We further show by simulations that the new approach achieves 80% reduction in the overall complexity compared to the conventional SD for a 2x2 system, and almost 50% reduction for the 4x4 and 6x6 cases, thus relaxing the requirements for hardware implementation.

Multi-antenna communication systems have the potential to play an important role in the design of the next generation broadband wireless communication systems. In this paper, we study a single-user multi-antenna system with perfect channel state information (CSI) both at the transmitter and the receiver. Beamforming is used to exploit the perfect channel knowledge at both ends. We show that beamforming achieves the maximum diversity in space when only the best eigenmode is used (i.e., single beamforming). We extend our analytical results to multiple beamforming (i.e., sending more than one symbol simultaneously). Our main contribution is the analysis of the maximum achievable diversity order of beamforming systems.