Intravenous paracetamol is effective in treating patients presenting with renal colic to the emergency department. CLINICAL TRIALS REGISTRATION NO: ClinicalTrials.gov ID number NCT01318187.
Intravenous paracetamol and dexketoprofen appear to produce equivalent pain relief for migraine in the emergency department. CLINICALTRIALS.GOV NO: NCT01730326.
Study objective The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED). Methods This randomised double-blind study compared the efficacy of intravenous 1 gm paracetamol, 50 mg dexketoprofen and 0.1 mg/kg morphine in patients with acute mechanical LBP. Visual analogue scale (VAS) was used for pain measurement at baseline, after 15 and after 30 min. Results A total of 874 patients were eligible for the study, and 137 of them were included in the final analysis: 46 patients from the paracetamol group, 46 patients in the dexketoprofen group and 45 patients in the morphine group. The mean age of study subjects was 31.5±9.5 years, and 60.6% (n=83) of them were men. The median reduction in VAS score at the 30th minute for the paracetamol group was 65 mm (95% CI 58 to 72), 67 mm (95% CI 60 to 73) for the morphine group and 58 mm (95% CI 50 to 64) for the dexketoprophen group. Although morphine was not superior to paracetamol at 30 min (difference: 3.8±4.9 (95% CI −6 to 14), the difference between morphine and dexketoprofen in reducing pain was 11.2±4.7 (95% CI 2 to 21). At least one adverse effect occurred in 8.7% (n=4) of the cases in the paracetamol group, 15.5% (n=7) of the morphine group, and 8.7% (n=4) of the dexketoprophen group ( p=0.482). Conclusions Intravenous paracetamol, dexketoprofen and morphine are not superior to each other for the treatment of mechanical LBP in ED.
AMAÇBu çalışma, acil servise başvuran tekstil ve giyim sektörü çalışanlarında işle ilgili yaralanmaları araştırmak için yapıldı.
GEREÇ VE YÖNTEMProspektif tasarlanan çalışmaya iki yıllık araştırma süresin-ce tekstil ve dokuma endüstrisinde çalışanların iş kazaları ile ilişkili başvurular alındı. Çalışma örnekleminde sadece iş yerinde ve fiilen çalışma sırasında olan yaralanmalar analiz edildi.
BULGULARToplam 374 hasta çalışma kriterlerine uygun bulundu. Olguların büyük bölümünü kadınlar (%76,2, n=285), yaş dilimleri içinde ise 14-24 yaş arasındakiler oluşturdu (%44,7, n=167). Olguların yaklaşık üçte ikisi iş kazasına bağ-lı olarak ilk kez hastaneye başvurduğunu bildirdi (%65,8, n=246). İş kazaları en sık 07:00 ile 09.00 (%27,3) ve 23:00 ile 01:00 (%17,9) saatleri arasında oluştu. Hastalar kazaların nedenini en sık olarak dikkatsizlik ve acelecilik olarak bildirdi (sırasıyla, %40,6 ve %21,4). Hastaların yaklaşık dörtte üçü olay sırasında koruyucu malzeme kullandığını bildirdi (%74,3, n=278). Yaralanma tiplerine bakıl-dığında, kesi/batma/amputasyon/ avulsiyon yaralanmaları %55,6 (n=208) oranındaydı. En sık olarak üst ekstremite yaralanması (%75,1 n=281) görüldü.
SONUÇÜlkemizde tekstil ve dokuma endüstrisinde çalışanların iş kazalarını bir bütün olarak tanımlamak için geniş, toplum tabanlı araştırmalara gereksinim vardır. Hızla gelişen bu sektörde iş kazalarının azaltılması için düzenlemeler yapıl-malıdır.Anahtar Sözcükler: Acil servis; mesleki yaralanmalar; tekstil sanayi; iş kazaları.
Pain management is one of the essentials of emergency care. Renal colic secondary to urinary stone disease forms one of the most intense pain types. The present study aimed to compare the effect of intravenous ibuprofen to paracetamol in ceasing renal colic. This randomised double-blind study was composed of two intervention arms, intravenous paracetamol and intravenous ibuprofen. Study subjects were randomised to receive a single dose of either paracetamol, 1 g in 100 ml normal saline, or ibuprofen (800 mg in 100 ml normal saline) in a blinded fashion. Subjects reported pain intensity on a visual analogue scale with lines intersection multiples of ten just before the drug administration, 15 and 30 min after the study drug administration. Two hundred patients were randomised to either of two study arms: however, 97 patients in ibuprofen group and 99 patients in paracetamol groups were included into 30 minute analysis. Differences of pain improvements between two groups was 9.5 (5.4-13.7) at 15 min (p = 0.000) and 17.1 (11.9-22.5) at 30 min, those both favouring ibuprofen over paracetamol (p = 0.000). Although ten (10.1%) patients in paracetamol group needed rescue drug, there were only two (2%) patients in ibuprofen group (difference: 8%; 95% CI 0.7-16%, p = 0.02). Intravenous 800 mg ibuprofen is more effective than IV paracetamol in ceasing renal colic at 30 min.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.