Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial

Serinken, Mustafa; Eken, Cenker; Turkcuer, Ibrahim; Eliçabuk, Hayri; Uyanık, Emrah; Schultz, Carl H.

doi:10.1136/emermed-2011-200165

Cited by 65 publications

(71 citation statements)

References 18 publications

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“…In a study by Serinken et al, effectiveness of intravenous paracetamol versus morphine for renal colic was investigated and it was concluded that intravenous paracetamol effectiveness, as an analgesic, was similar to morphine while bearing less side effects (28); the results of this study are similar to the present study and the only difference between these studies is administration of diclofenac beside morphine in control group, while Serinken et al, only used morphine in control group. In another study by Grissa et al, comparing effectiveness of intravenous paracetamol and piroxicam in renal colic, it was concluded that paracetamol was statistically more effective than piroxicam (29); results of this study was similar to present study.…”

Section: Discussionsupporting

confidence: 80%

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

et al. 2018

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Background: Renal colic is one of the most prevalent diagnoses made in emergency departments. Main medications used to relieve renal colic is opioids and non-steroidal anti-inflammatory drugs (NSAID). As far as these medications may have some side effects, researchers have always focused on proposing analgesics with more efficacy and less side effects. In the present study, it was tried to compare paracetamol and intravenous morphine plus diclofenac in renal colic.

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Section: Discussionsupporting

confidence: 80%

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

et al. 2018

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“…Opioids are commonly used to manage pain in patients with AP, although there are some unclear points with regard to their clinical effectiveness and safety (1,4). In contrast, intravenous paracetamol is a cyclooxygenase inhibitor that has been documented to have comparable effectiveness with opioids in the last decades in an emergency setting and in various acute pain patterns (5,6).…”

Section: Introductionmentioning

confidence: 99%

Pain treatment in patients with acute pancreatitis: A randomized controlled trial

Gülen

Dur²,

Serinken³

et al. 2016

Turk J Gastroenterol

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“…Results of the similar studies did not show any significant difference in the analgesic effect of intravenous acetaminophen and morphine (3)(4)(5)(6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 82%

“…A single-blind emergency department study over patients presenting with renal colic found that intravenous acetaminophen was equally effective as intravenous morphine (3). There are also some other studies showing that intravenous acetaminophen is as effective as intravenous morphine in pain management (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Intravenous Acetaminophen Versus Intravenous Morphine Sulfate for Isolated Diaphyseal Long Bone Fractures: A Randomized Clinical Trial

Deloee¹,

Zarmehri²,

Pishbin³

et al. 2017

Trauma Mon

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Objectives: Pain management is an important issue in traumatic patients. The aim of this randomized clinical trial was to compare the analgesic effect of intravenous acetaminophen with intravenous morphine sulfate in patients with traumatic diaphyseal long bone fracture. Methods: This double-blind randomized clinical trial was carried out in an academic trauma center in Mashhad, Iran, from February to October 2013. After primary modalities like limb elevation, ice and limb splinting, patients were allocated to receive either acetaminophen 15 mg/kg or morphine sulfate 0.1 mg/kg randomly. The pain severity was measured using a visual analogue scale before drug administration and 5 and 30 minutes after drug administration. Then, the results were compared. Results: Of the 50 patients recruited over 9 months 26 patients received intravenous morphine sulfate and 24 patients received intravenous acetaminophen. A significant difference was observed between the two groups at 5 minutes after drug administration; the morphine sulfate group showed more reduction in pain severity after 5 minutes (P < 0.0001). However, there was no significant difference in pain severity at 30 minutes after drug administration between the two groups (P = 0.85). Conclusions: It seems that after 30 minutes, intravenous acetaminophen is as effective as intravenous morphine sulfate in pain management of isolated diaphyseal long bone fracture. However, it should be noted that the analgesic effect of acetaminophen begins with a delay. Thus, we suggest using intravenous acetaminophen when morphine administration is contraindicated.

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Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial

Abstract: Intravenous paracetamol is effective in treating patients presenting with renal colic to the emergency department. CLINICAL TRIALS REGISTRATION NO: ClinicalTrials.gov ID number NCT01318187.

Cited by 65 publications

References 18 publications

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Pain treatment in patients with acute pancreatitis: A randomized controlled trial

Intravenous Acetaminophen Versus Intravenous Morphine Sulfate for Isolated Diaphyseal Long Bone Fractures: A Randomized Clinical Trial

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