No abstract

Background: Up to half of patients with dementia may not receive a formal diagnosis, limiting access to appropriate services. It is hypothesised that it may be possible to identify undiagnosed dementia from a profile of symptoms recorded in routine clinical practice.

Recent years have seen increasing growth and popularity of gaming services, both interactive and passive. While interactive gaming video streaming applications have received much attention, passive gaming video streaming, in-spite of its huge success and growth in recent years, has seen much less interest from the research community. For the continued growth of such services in the future, it is imperative that the end user gaming quality of experience (QoE) is estimated so that it can be controlled and maximized to ensure user acceptance. Previous quality assessment studies have shown not so satisfactory performance of existing No-reference (NR) video quality assessment (VQA) metrics. Also, due to the inherent nature and different requirements of gaming video streaming applications, as well as the fact that gaming videos are perceived differently from non-gaming content (as they are usually computer generated and contain artificial/synthetic content), there is a need for application-specific lightweight , no-reference gaming video quality prediction models. In this paper, we present two NR machine learning-based quality estimation models for gaming video streaming, NR-GVSQI, and NR-GVSQE, using NR features, such as bitrate, resolution, and temporal information. We evaluate their performance on different gaming video datasets and show that the proposed models outperform the current state-of-the-art no-reference metrics, while also reaching a prediction accuracy comparable to the best known full reference metric. INDEX TERMS Quality assessment, no reference, gaming video streaming, machine learning, regression, quality of experience, video quality metrics.

Alzheimer's disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the early stages would be useful for early diagnosis of AD, but this would involve dealing with large numbers of people because up to 50% of dementia sufferers do not receive formal diagnosis. Thus, there is a need for accurate, low-cost, and easy to use biomarkers that could be used to detect AD in its early stages. Potentially, electroencephalogram (EEG) based biomarkers can play a vital role in early diagnosis of AD as they can fulfill these needs. This is a cross-sectional study that aims to demonstrate the usefulness of EEG complexity measures in early AD diagnosis. We have focused on the three complexity methods which have shown the greatest promise in the detection of AD, Tsallis entropy (TsEn), Higuchi Fractal Dimension (HFD), and Lempel-Ziv complexity (LZC) methods. Unlike previous approaches, in this study, the complexity measures are derived from EEG frequency bands (instead of the entire EEG) as EEG activities have significant association with AD and this has led to enhanced performance. The results show that AD patients have significantly lower TsEn, HFD, and LZC values for specific EEG frequency bands and for specific EEG channels and that this information can be used to detect AD with a sensitivity and specificity of more than 90%.

Alzheimer's disease (AD) and other forms of dementia are one of the major public health and social challenges of our time because of the large number of people affected. Early diagnosis is important for patients and their families to get maximum benefits from access to health and social care services and to plan for the future. EEG provides useful insight into brain functions and can play a useful role as a first line of decision-support tool for early detection and diagnosis of dementia. It is non-invasive, low-cost and has a high temporal resolution. The functions of brain cells are affected by damage caused by dementia and this in turn causes changes in the features of the EEG. Information theoretic methods have emerged as a potentially useful way to quantify changes in the EEG as biomarkers of dementia. Tsallis entropy has been shown to be one of the most promising information theoretic methods for quantifying changes in the EEG. In this paper, we develop the approach further. This has yielded an enhanced performance compared to existing approaches.