Targeted drug delivery by magnetic nanoparticles (MNPs) is at the leading edge of the rapidly developed methods for the diagnosis and treatment of various diseases. Functionalization of nonsteroidal anti-inflammatory drugs (NSAIDs) onto MNP-based platforms constitutes a challenging endeavor, as it is based on the physicochemical characteristics of the final carrier/system. MnFe 2 O 4 MNPs of relatively small size and enhanced magnetization with aminated (AmMNPs) and non-aminated (Non-AmMNPs) surface were prepared solvothermally in the presence of octadecylamine(ODA) through synthetic variations. Three nonsteroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA), mefenamic acid (MEF) and Naproxen (NAP), of different pharmacochemical properties, were used for [a]
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