Nanoplatforms of Manganese Ferrite Nanoparticles Functionalized with Anti‐Inflammatory Drugs

Abstract

Targeted drug delivery by magnetic nanoparticles (MNPs) is at the leading edge of the rapidly developed methods for the diagnosis and treatment of various diseases. Functionalization of nonsteroidal anti-inflammatory drugs (NSAIDs) onto MNP-based platforms constitutes a challenging endeavor, as it is based on the physicochemical characteristics of the final carrier/system. MnFe 2 O 4 MNPs of relatively small size and enhanced magnetization with aminated (AmMNPs) and non-aminated (Non-AmMNPs) surface were prepared solvothermally in the presence of octadecylamine(ODA) through synthetic variations. Three nonsteroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA), mefenamic acid (MEF) and Naproxen (NAP), of different pharmacochemical properties, were used for [a]

Stimuli-responsive spin crossover nanoparticles for drug delivery and DNA-binding studies

“…During the last decade, inorganic nanoparticles (NPs) such as gold, silver, platinum, iron oxide, manganese-ferrite oxide and zinc oxide derivatives [1][2][3][4][5] have been widely utilized among other organic counterparts (liposomes, polymers, and carbon) [6][7][8] in biomedical applications in order to improve the therapeutic efficacy of drugs. Coordination complexes/polymers may also act as drug delivery systems and carry a wide range of bioactive molecules or accommodate multiple functional groups.…”

Interaction of ZnO Nanostructures with Proteins: In Vitro Fibrillation/Antifibrillation Studies and in Silico Molecular Docking Simulations

“…31 Fourier transform infrared spectra (FTIR) (450−4000 cm −1 ) and thermogravimetric analysis (TGA) were obtained using the instruments and the preparation method previously reported. 19 Fluorescence spectra were recorded in solution on a Hitachi F-7000 fluorescence spectrophotometer.…”

“…X-ray powder diffraction (XRD) measurements and conventional transmission electron microscopy (TEM) images were obtained with the same setup and under the specific conditions described elsewhere . Fourier transform infrared spectra (FTIR) (450–4000 cm –1 ) and thermogravimetric analysis (TGA) were obtained using the instruments and the preparation method previously reported . Fluorescence spectra were recorded in solution on a Hitachi F-7000 fluorescence spectrophotometer.…”

“…6 Meanwhile, an in vitro electrokinetic approach was proposed for evaluating the amyloid degradation ability of ZnO NPs. 16 In this work, expanding our former research on biomedical applications of metal oxide nanoparticles, 17,18,19,20,21,22,23 we report the wet chemical synthesis of ZnO nanostructures of different morphology, to study their effect on amyloid fibrils formation and degradation in two model proteins; human insulin (HI) and bovine serum albumin (BSA). HI, a blood glucose regulation hormone, can form amyloid fibrils in vitro when agitated and/or at acidic pH, 24 while BSA beyond its amyloidogenic property, 25 is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules.…”

“…In this work, based on our previous experience on preparation and biomedical applications of metal oxide nanoparticles, − we report the wet chemical synthesis of ZnO nanostructures of different morphology to study their fibrillation/antifibrillation ability on amyloids in human insulin (HI) and bovine serum albumin (BSA), which constitute model proteins. HI is a peptide hormone, which can form in vitro insoluble fibril aggregations under certain experimental parameters, e.g., at low pH and after shaking .…”