Stimuli-responsive spin crossover nanoparticles for drug delivery and DNA-binding studies

Abstract

Aminated silica hybrid, spin-crossover (SCO) nanoparticles (AmNPs) coupled with (S)-naproxen (NAP) are good candidates for drug nanocarriers.

pH-Sensitive Gold Nanorods for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Delivery and DNA-Binding Studies

“…Given the molecular mass of NAP (230.2 g/mol), the corresponding constants could be expressed in mg/mL and are much higher than those of AuNRs@PEG@NAP. In addition, the constant of AuNRs@PEG@NAP could be considered comparable with those of a previously reported carbon nanotube and spin-crossover nanoparticle loaded with naproxen [43,44].…”

“…Taken into consideration the molecular mass of NAP (230.2), its corresponding constants may also be expressed in mg/mL (Table 4) and, especially the value of K HSA , are much higher than those of AuNRs@PEG@NAP. The binding of AuNRs@PEG@NAP to albumins is reversible and relatively tight when compared to previously reported carriers of naproxen [43,44].…”

“…This may suggest that the incorporation of naproxen in the AuNRs@PEG may lead to a tighter interaction with CT DNA than the free NAP. A comparison of the DNA-binding constant of AuNRs@PEG@NAP with the reported metal-naproxen complexes may reveal that AuNRs@PEG@NAP is a slightly tighter DNA-binder than the Co(II) [37], Cu(II) [38], and most Mn(II) [35,36] complexes of naproxen, and similar to Sn(IV) [41] and Ag(I) [42] complexes, while the polyethyleneimine-functionalized carbon nanotube hosting naproxen [43], the water-soluble silica hybrid spin-crossover nanoparticle loaded with naproxen [44], and the reported Ni(II)-naproxen complexes present higher K b values [39] than AuNRs@PEG@NAP.…”

Observation of two-step spin transition in iron(ii) 4-amino-1,2,4-triazole based spin crossover nanoparticles

“…1 It is therefore of utmost importance to correlate the SCO properties as a function of the size of SCO nanoparticles. Although there has been extensive research study for the case of 1D coordination polymers (CPs) of [Fe(Htrz)(trz) 2 ]BF 4 · x H 2 O 2–13 less attention is paid to the 1D CP of [Fe(NH 2 trz) 3 ](anion) 2 · x H 2 O. Conclusions have been drawn from studies in [Fe(NH 2 trz) 3 ] Br 2 ·3H 2 O, according to which NPs with dimensions 30–50 nm present considerably reduced thermal hysteresis width to values close to 2 K and critical temperatures T 1 = 312 K, T 2 = 310 K. 14–16 For macroscopic or micrometric particles the upper limit of T 1 value was found to be 320 K with thermal width of 15 K. 14–16 For the above mentioned NPs (will be referenced as NPL ) a reverse micellar method was followed using the non-ionic surfactant Lauropal playing the role of surfactant and oil.…”

Nanocomposites Based on Spin-Crossover Nanoparticles and Silica-Coated Gold Nanorods: A Nonlinear Optical Study

“…Another interesting aspect of SCO compounds is the influence of their size and shape on the SCO properties, leading to novel processing methods for SCO materials at the nanometric scale [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. A lot of attention has been given to the family of 1D coordination triazole-based Fe(II) compounds, as their SCO macroscopic properties are retained at the nanometric scale [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”