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In this work a new methodology is proposed to correct the thermal lag error in data from unpumped CTD sensors installed on Slocum gliders. The advantage of the new approach is twofold: first, it takes into account the variable speed of the glider; and second, it can be applied to CTD profiles from an autonomous platform either with or without a reference cast. The proposed methodology finds values for four correction parameters that minimize the area between two temperature-salinity curves given by two CTD profiles. A field experiment with a Slocum glider and a standard CTD was conducted to test the method. Thermal lag-induced salinity error of about 0.3 psu was found and successfully corrected.

During winter 2012–2013, open‐ocean deep convection which is a major driver for the thermohaline circulation and ventilation of the ocean, occurred in the Gulf of Lions (Northwestern Mediterranean Sea) and has been thoroughly documented thanks in particular to the deployment of several gliders, Argo profiling floats, several dedicated ship cruises, and a mooring array during a period of about a year. Thanks to these intense observational efforts, we show that deep convection reached the bottom in winter early in February 2013 in a area of maximum 28 ± 3 109normalm2. We present new quantitative results with estimates of heat and salt content at the subbasin scale at different time scales (on the seasonal scale to a 10 days basis) through optimal interpolation techniques, and robust estimates of the deep water formation rate of 2.0 ±0.2 Sv. We provide an overview of the spatiotemporal coverage that has been reached throughout the seasons this year and we highlight some results based on data analysis and numerical modeling that are presented in this special issue. They concern key circulation features for the deep convection and the subsequent bloom such as Submesoscale Coherent Vortices (SCVs), the plumes, and symmetric instability at the edge of the deep convection area.

Recent data from an autonomous ocean glider in the Ibiza Channel (Western Mediterranean Sea) show variations in the transport volumes of water over timescales of days‐weeks, as large as those previously only identifiable as seasonal or eddy driven. High frequency variation in transports of water masses has critical implications for ocean forecasting. Three potential modes of transport are proposed, which have the potential to simplify the previously observed complex pattern of flows. Restricted ‘choke points’ between ocean basins are critical locations to monitor water transport variability; the Ibiza Channel is one such ‘choke point’, where variation in the transports of water masses are known to affect the spawning grounds of commercially important fish stocks.

Objective: To determine whether postnatal mother-infant sleep proximity affects breastfeeding initiation and infant safety. Design: Randomised non-blinded trial analysed by intention to treat. Setting: Postnatal wards of the Royal Victoria Hospital (RVI), Newcastle upon Tyne, UK. Participants: 64 newly delivered mother-infant dyads with a prenatal intention to breastfeed (vaginal deliveries, no intramuscular or intravenous opiate analgesics taken in the preceding 24 h). Intervention: Infants were randomly allocated to one of three sleep conditions: baby in mother's bed with cot-side; baby in side-car crib attached to mother's bed; and baby in stand-alone cot adjacent to mother's bed. Main outcome measures: Breastfeeding frequency and infant safety observed via night-time video recordings. Results: During standardised 4-h observation periods, bed and side-car crib infants breastfed more frequently than stand-alone cot infants (mean difference (95% confidence interval (CI)): bed v stand-alone cot = 2.56 (0.72 to 4.41); side-car crib v stand-alone cot = 2.52 (0.87 to 4.17); bed v side-car crib = 0.04 (22.10 to 2.18)). No infant experienced adverse events; however, bed infants were more frequently considered to be in potentially adverse situations (mean difference (95% CI): bed v stand-alone cot = 0.13 (0.03 to 0.23); side-car crib v stand-alone cot = 0.04 (20.03 to 0.12); bed v side-car crib = 0.09 (20.03-0.21)). No differences were observed in duration of maternal or infant sleep, frequency or duration of assistance provided by staff, or maternal rating of postnatal satisfaction. Conclusion: Suckling frequency in the early postpartum period is a well-known predictor of successful breastfeeding initiation. Newborn babies sleeping in close proximity to their mothers (bedding-in) facilitates frequent feeding in comparison with rooming-in. None of the three sleep conditions was associated with adverse events, although infrequent, potential risks may have occurred in the bed group. Side-car cribs are effective in enhancing breastfeeding initiation and preserving infant safety in the postnatal ward.A lthough the beneficial effects of early and frequent suckling and skin-to-skin contact on breastfeeding initiation are well known, [1][2][3][4][5][6] there has been little work on the effect of subsequent mother-infant contact in the initial postnatal days. Night-time rooming-in has been shown to enhance breastfeeding on demand in comparison with night-time nursery care 7 8 ; however, ''rooming-in'' involves babies sleeping in stand-alone cots that do not allow continuous contact or spontaneous feeding between mothers and infants. Yet, such contact may be of importance for mothers to understand their babies' signals and to respond effectively.Unhindered contact can only be provided for mother and baby at night in the postnatal ward through some arrangement whereby both of them can maintain continuous contact to allow spontaneous breastfeeding. Two forms of bedding-in currently practised in UK hospitals include either the ba...

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Duchenne muscular dystrophy (DMD) is an X-linked genetic disease, caused by the absence of the dystrophin protein. Although many novel therapies are under development for DMD, there is currently no cure and affected individuals are often confined to a wheelchair by their teens and die in their twenties/thirties. DMD is a rare disease (prevalence <5/10,000). Even the largest countries do not have enough affected patients to rigorously assess novel therapies, unravel genetic complexities, and determine patient outcomes. TREAT-NMD is a worldwide network for neuromuscular diseases that provides an infrastructure to support the delivery of promising new therapies for patients. The harmonized implementation of national and ultimately global patient registries has been central to the success of TREAT-NMD. For the DMD registries within TREAT-NMD, individual countries have chosen to collect patient information in the form of standardized patient registries to increase the overall patient population on which clinical outcomes and new technologies can be assessed. The registries comprise more than 13,500 patients from 31 different countries. Here, we describe how the TREAT-NMD national patient registries for DMD were established. We look at their continued growth and assess how successful they have been at fostering collaboration between academia, patient organizations, and industry.

The OceanGliders program started in 2016 to support active coordination and enhancement of global glider activity. OceanGliders contributes to the international efforts of the Global Ocean Observation System (GOOS) for Climate, Ocean Health, and Operational Services. It brings together marine scientists and engineers operating gliders around the world: (1) to observe the long-term physical, biogeochemical, and biological ocean processes and phenomena that are relevant for societal applications; and, (2) to contribute to the GOOS through real-time and delayed mode data dissemination. The OceanGliders program is distributed across national and regional observing systems and significantly contributes to integrated, multi-scale and multi-platform sampling strategies. OceanGliders shares best practices, requirements, and scientific knowledge needed for glider operations, data collection and analysis. It also monitors global glider activity and supports the dissemination of glider data through regional and global databases, in realtime and delayed modes, facilitating data access to the wider community. OceanGliders currently supports national, regional and global initiatives to maintain and expand the capabilities and application of gliders to meet key global challenges such as improved measurement of ocean boundary currents, water transformation and storm forecast.