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Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial dynamics in mitigating such processes and their impact on muscle fitness remain unaddressed. Here we report that opposite mitochondrial morphologies induce distinct inflammatory signatures, caused by differential activation of DNA sensors TLR9 or cGAS. In the context of mitochondrial fragmentation, we demonstrate that mitochondria-endosome contacts mediated by the endosomal protein Rab5C are required in TLR9 activation in cells. Skeletal muscle mitochondrial fragmentation promotes TLR9-dependent inflammation, muscle atrophy, reduced physical performance and enhanced IL6 response to exercise, which improved upon chronic anti-inflammatory treatment. Taken together, our data demonstrate that mitochondrial dynamics is key in preventing sterile inflammatory responses, which precede the development of muscle atrophy and impaired physical performance. Thus, we propose the targeting of mitochondrial dynamics as an approach to treating disorders characterized by chronic inflammation and mitochondrial dysfunction.

Scholarly understanding of emotions and emotion regulation rests on two incompatible truths-that positive emotions are positively beneficial and should be pursued, and that changing emotions may come at a cost. With both perspectives in mind, to really conclude that pursuing higher positive affect (PA) is a worthy journey, we must take into account the cost of that journey itself. We build from the affect shift literature and draw on self-regulation theories to argue that, although end-states characterized by more positive (and fewer negative) emotions will be beneficial, the emotional changes required to "get there" will have consequences for employee regulatory resources and subsequent behavior. In Study 1, we use experience sampling methodology to track employee emotional journeys-changes in emotions in terms of directionality (e.g., toward pleasure and away from pain) and distance (i.e., magnitude of change in terms of intensity changes within-emotions as well as magnitude of change in activation/valence level between emotions)that capture the amount of emotion regulation preceding emotion end-states. Teasing apart variance attributable to the end-state versus the journey, we demonstrate that steeper daily PA trajectories (steeper increases in intensity of positive, activated emotions) and valence trajectories (steeper movement away from more negative emotions toward more positive emotions) lead to psychological depletion, ultimately triggering interpersonal counterproductive work behaviors and harming citizenship and performance. In Study 2, we test our core propositions in a lab experiment, demonstrating that different emotional journeys "leading up" to the same affective end-state can change the meaning of that end-state.

Objective To explore the ways in which same‐sex adoptive parents navigate the process of determining what terms their children will use to address them (i.e., parent names). Background Parent names are markers of familial relationships and identity. Different‐sex parents are linguistically privileged in that their parent names are widely recognizable, easily distinguishable between each parent, and usually assigned by default as opposed to chosen, whereas parents in same‐sex couples must go through a deliberate process of choosing parent names. Little is known about the naming process for same‐sex parents. Method This qualitative analysis was designed to explore 40 same‐sex adoptive parent couples' approaches to parent naming (20 gay couples, 20 lesbian couples). Results Most couples collaboratively selected parallel names (e.g., “Daddy” and “Papa”). Participants drew on traditional mother and father derivatives, as well as their cultural backgrounds and naming trends within queer family communities. Families who adopted older children navigated unique issues. Conclusion This study adds to the literatures on same‐sex parenting, adoptive parenting, and naming. Families highlighted the perceived importance of parallel names and collaborative naming processes; the consideration of cultural backgrounds and other same‐sex parent families in naming; and naming challenges related to child age, the gender binary, and stigma. Implications Results shed light on various sources and considerations that may shape parent naming, which can inform the work of therapists and other providers who work with same‐sex parent families, particularly during the transition to parenthood.

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