Raloxifene, a member of the class of selective estrogen receptor modulators (SERM), reproduces the beneficial effects of estrogens on the skeletal systems, without the negative effects estrogens on breast and endometrium. This is a review article summarizing its mechanism, effects on bone and its applicability in traumatology clinical practice. In postmenopausal osteoporosis, this drug has been proven to decrease accelerated bone turnover, increase bone mineral density (BMD), and to structurally recover bone, decreasing the risk of vertebral fractures and the risk of non-vertebral fractures in patients with previous, severe vertebral fractures. Moreover, raloxifene appears to lower the risk of invasive breast cancer. Raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis.We can therefore conclude that raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis, while reducing the risk of breast cancer when used at the indicated dose of 60 mg/day and with a low incidence of side effects.
Rutger J. Allan: The Middle Voice in Ancient Greek. A Study in Polysemy. Amsterdam: Gieben 2003. VIII, 278 S. (Amsterdam Studies in Classical Philology. 11.) 72 €.
The purpose of this paper is to show that four subclasses of adjectives can be set up in Ancient Greek. To such an aim a number of morphosyntactic tests is used in order to find out the features shared by each group of adjectives as well as the properties keeping each subclass apart. In the light of the applied tests, four groups are established; they can be called, according to their semantic features: determiners, identifiers, quantifiers and qualifiers. It goes without saying that it is be counted with the existence of historical changes as to the actual subclassification of each item
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