4. Laryngoscope, 128:701-706, 2018.

Objective: Time-processing disorders in adults is a priority area for intervention. Time management program, which has been demonstrated to be effective in children with ADHD, has not been examined in adults. We anticipate the need for the development of specialized programs for adults. This is because it has been reported that time processing disorders have different patterns in childhood and adulthood. This study aimed to evaluate the therapeutic effect of a gCBT program focusing on time management for adults with ADHD. Method: Adults with ADHD were randomly assigned to gCBT ( n = 24) or a treatment as usual group ( n = 24). Outcome measures were masked clinically rated, self-reported, and family-reported ADHD symptoms. Results: The gCBT group significantly reduced ADHD symptoms on all measures. Conclusion: Interventions focused on time management have been shown to be effective not only in children with ADHD but also in adult patients.

Objectives: To determine the prevalence and risk factors for isolation of drug-resistant Escherichia coli (E. coli) in patients with complicated cystitis. Methods: We analyzed 170 patients with complicated cystitis and urine culture was positive for E. coli in all of them. Detailed clinical features were identified and risk factors for isolation of drug-resistant E. coli were determined. Results: The drug susceptibilities of 170 isolates to levofloxacin and cefotaxime or cefpirome were 77% and 96%, respectively. Fluoroquinolone-resistant E. coli (FQREc) was detected at least once in 39 patients. Prior use of fluoroquinolones within 1 month, between 1 and 3 months, and hospitalization were risk factors for FQREc infection (P < 0.05), with odds ratios of 24 (95% confidence interval [CI] 6.4-89), 4.7 (95% CI 1.8-12), and 3.1 (95% CI 1.4-6.8), respectively. All six organisms resistant to cephems were extended-spectrum beta-lactamase (ESBL)-producing E. coli. The isolation of ESBLproducing E. coli tended to be more frequent in patients who were hospitalized (P < 0.05), with an odds ratio of 7.9 (95% CI 1.4-45). There was no significant correlation between growth rate of ESBL-producing E. coli and prior use of antibiotics. Conclusions: The frequencies of FQREc and ESBL-producing E. coli were 23% and 4%, respectively. Prior use of fluoroquinolones within 3 months and hospitalization were risk factors for FQREc. Hospitalization was a risk factor for ESBLproducing E. coli infection.

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Objectives It is generally thought that the recovery of damaged chorda tympani nerve (CTN) function after middle ear surgery is different in pediatric patients from that in adult patients. The purpose of this study was to investigate the changes and the progress of taste and somatosensory functions of the tongue after middle ear surgery in pediatric patients compared with those of adult patients. Study Design Prospective study. Methods Fifty‐nine pediatric patients and 106 adult patients underwent middle ear surgery. Taste and somatosensory functions of the anterior tongue, the so‐called CTN functions, were assessed using electrogustometry (EGM), a 2‐point discriminator, an electrostimulator, and a questionnaire before and 2 weeks and 6 months after surgery. Results Two weeks after surgery, there was no significant difference in the incidence of dysgeusia and abnormal EGM thresholds between the patient groups. The incidence of tongue numbness was significantly lower in pediatric patients than in adult patients regardless of CTN manipulation. Although the lingual somatosensory thresholds of adult patients were significantly increased, those of pediatric patients were not increased. Six months after surgery, the incidences of dysgeusia and an abnormal EGM threshold were lower in pediatric patients than in adult patients. Tongue numbness disappeared, and the thresholds of lingual somatosensory tests returned to normal in most pediatric patients. Conclusion Not only taste function but also lingual somatosensory function was damaged after middle ear surgery even in pediatric patients. Pediatric patients complained of tongue numbness less frequently and showed earlier recovery than adult patients. Level of Evidence 2 Laryngoscope, 130:1016–1022, 2020

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We report herein on 15 cases of pulmonary metastases from squamous cell carcinoma of the head and neck (SCCHN) treated with modified TPF chemotherapy (docetaxel combined with nedaplatin and 5-FU). TPF chemotherapy is known as a neoajuvant chemotherapy regimen. We modified the TPF chemotherapy using nedaplatin as a substitute for cisplatin. We tried 4 courses of modified TPF chemotherapy every 3 weeks, docetaxel 60 mg/m 2 on day 1; nedaplatin 75 mg/m 2 on day 1 and 5-FU 1000 mg/body by continuous infusion on days 1 to 4. 11 patients received 4 courses, and the remaining of 4 patients recieved 1-3 courses because of their poor general condition. Of the 15 patients, 13 were males and 2 were females with ages ranging from 43 to 73 years (mean, 59.1 yr). Two of the primary sites were in the nasopharynx, 2 in orophanrynx, 4 in the hypopharynx, 2 in the larynx and 4 in the oral cavity. Clinically there were 7 complete responders, 4 partial responders, 2 with no change, and 2 with progressive disease. The mean overall survival was 46.5 months. TPF chemotherapy may improve the overall survival.

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