It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma. An increase in rat mucosal glandular lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in gastric ulceration induced by cold retention stress were observed, whereas in patients with ulcerated clinical peptic and gastric carcinoma LPO serum is associated with a decrease in SOD and CAT. It was intended to determine the parameters of oxidative stress in the blood and brain in rats after induction of gastric ulcer, the effect of antioxidant treatment on these parameters and on the appearance of gastric ulcer, determination of correlation between oxidative stress and severity of gastric ulcer in rats and also evaluation of vascular endothelial function by in vitro studies in the organ bath, from rat aortic rings with gastric ulcer vs. normal and others under treatment vs. untreated.
Although oxidative stress itself is directly associated with the occurrence of atherosclerosis, and together with endothelial dysfunction is a marker of atherosclerotic risk, none of these two markers were directly correlated with the presence of atherosclerosis. This study investigated the correlation between oxidative stress and endothelial dysfunction in people with cardiovascular disease. Furthermore, another objective of this paper is the direct study of the effect of a compound with antioxidant properties, selenium, on a model of endothelial dysfunction induced on human vascular fragments.
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