O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1 H e de 13 C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1 H and 13 C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.

This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K2[PtCl4] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.

Six new platinum(II) complexes containing a diamino sugar, analogs of cisplatin and carboplatin, have been prepared and characterized. The new ligands were obtained by reaction of D-galactose and D-ribose derivatives with ethylenediamine.

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