Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

Abstract

O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1 H e de 13 C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1 H and 13 C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.

Novel platinum(II) complexes of long chain aliphatic diamine ligands with oxalato as the leaving group: comparative cytotoxic activity relative to chloride precursors

“…These chemical shift values are in agreement with data reported for similar compounds in the literature. [16][17][18] As expected, a shift to high frequency was observed, caused by the replacement of the chloride by oxalato, which altered the coordination sphere around the platinum ion.…”

Síntese e caracterização de novos complexos de platina (II) com ligantes derivados do furano e nitrofurano

“…Os complexos apresentaram sinal entre δ -2321 e -2226. Este valor de deslocamento químico está condizente com complexos similares encontrados na literatura, nos quais a platina apresenta na sua esfera de coordenação dois cloretos e dois átomos de nitrogênio 22 .…”

Synthesis, Characterization, and Cytotoxic Activity of Novel Platinum(II) Complexes Derived from N‐Benzyl‐Ethylenediamine and Oxalate

“…These compounds were obtained as described by de Almeida et al (19). The corresponding benzyl chloride was added slowly during 4 h to an excess of ethylenediamine in ethanol.…”

“…The three novel platinum(II) complexes were synthesized from K 2 PtCl 4 previously reacted with the corresponding N-benzyl-ethylenediamine ligands to obtain the precursor complexes (19), and then, the chloride ligands were substituted by oxalate as shown in Scheme 1. To the precursor complexes (1 mmol) in water (20 mL) was added 20 mL of aqueous solution of Ag 2 C 2 O 4 (0.303 g; 1 M).…”