Introduction: Subtle neurocognitive deficits have been recently observed in Acute Lym-phoblastic Leukemia (ALL) survivors.Aim: We aim to assess the neurocognitive functions of ALL survivors who had been treated with chemotherapy only using two different protocols, and to identify treatment-related risk factors.Patients and Methods: We carried a multicenter study involving 3 pediatric oncology centers on 100 children who were treated for ALL. Fifty patients were treated by the modified Children’s Cancer Group (CCG) 1991 protocol with low dose methotrexate and 50 children were treated by Total XV protocol with high dose methotrexate. Fifty healthy children were included as a control group. Psy-chometric assessment using Arabic version of Wechsler intelligence scale for children (WISC III) was performed for all patients and controls.Results: Patients had significantly lower mean full scale IQ, performance IQ and verbal IQ than con-trols. Patients ≤ 5 years at diagnosis had significantly lower mean full scale IQ and performance IQ than patients>5 years at diagnosis, while the verbal IQ showed no significant difference between both age groups. Female patients had significantly lower mean full scale IQ, performance IQ and verbal IQthan males. Patients who received Total XV protocol with high dose methotrexate had significantly lower mean full scale IQ, performance IQ and verbal IQ than patients who received modified CCG 1991 protocol with low dose methotrexate.Conclusions: CNS directed chemotherapy might appear to affect neurocognitive functions in chil-dren with ALL, which is more significant in young children at diagnosis, in girls and in those receiv-ing high dose methotrexate.

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Background: Eating disorders are complex psychiatric syndromes in which cognitive distortions related to food and body weight and disturbed eating patterns can lead to significant and potentially life threatening medical and nutrition complications. Aim of the work: To evaluate the prevalence of subclinical form of eating disorders and the association between it and mood disorders (Major Depressive disorder, Dysthymia) and anxiety disorders in adolescent girls in Sharkia governorate Subject and Methods: in this two-stage cross-sectional study, we screened 2000 secondary school-student girls using (EDT) ,and CSID-1(for eating disorders) .Those scoring more than 30in EDT, and +ve SCID-1 (N=471) and a control group randomly selected from those scoring lower than 30, and-ve SCID-1 for eating disorders (N=215). To differentiate types of eating disorders (anorexia nervosa, bulimia nervosa, and EDNOS (subclinical eating disorders). All subjects(+ve SCID-1) involved in stage 2 were examined for mood disorders (depression, dysthymia) by using beck scale for depression, SCIA-I scale for dysthymia, and anxiety disorders by using taylor scale. Results: the prevalence of subclinical eating disorders were 25.5% (SAN 3.5%, SBN 3.0%, SWC 10.0% and SBED 9.0%), there were statistically significant differences in socio-demographic data between the SEDS groups (Subclinical anorexia nervosa is low significant in BMI than other groups), Prevalencedepressive disorder 10.8%, MDD in SEDS patients were 2.5%, dysthymic disorder 4.0 % and generalized anxiety disorder 5.4%. Conclusion: Subclinical eating disorders are more frequent than typical eating disorders. Subclinical forms of eating disorders may represent a high risk group for developing serious eating disorders, identifying this group will give an opportunity of prevention. Mood disorders (MDD, dysthymia) and generalized anxiety disorder are more frequent in subclinical eating disorders. Key words Eating disorders| Subclinical eating disorders| Eating disorder test| Mood disorders| MDD| Dysthymic disorder| Generalized anxiety disorder.