Background: Bacterial pneumonia of is common cause of pediatric mortality and hospital admission. Different risk factors for pneumonia are there. One possible risk factor is vitamin D deficiency .Objective: We determined 25 OH-vitamin D in bacterial pneumonia.to evaluate whether its level has relation to pathogenesis and management of the disease Design: case-control study Methods: 25 OH-vitamin D was determined by competitive enzyme immunoassay (EIA) commercially available kit in 36 cases with pneumonia CRP was determined by ELIZA "high sensitive CRP" .ESR done by Wintrobe method The results were analyzed and compared with 16 controls using SPSS 20 Results: Vitamin D level in pneumonia cases was significantly lower in patients compared to controls a n d s h o w e d n e g a t i v e c o r r e l a t i o n w i t h C -r e a c t i v e p r o t e i n and weak negative correlation ESR. Vitamin D did not show any relation to age, sex, weight or other clinical symptoms as dyspnea and fever Also did not show any relation to RBCs, Hb, or WBCs .Conclusion: We conclude that level of 25 OH-vitamin D is low in children with bacterial pneumonia and correlates negatively with CRP with possible relation to disease severity.
Trace elements are micronutrient present in small amount in the body they have antioxidant and immune-regulatory function and possibly have role in pathogenesis in infant wheezes. We estimated serum level of copper .zinc magnesium in 30 wheezy infants versus 10 control Both groups were age, sex and weight matched. Serum copper, magnesium was significantly higher in patient versus control (48.6±36.8 &2.57± 0.69 respectively in cases vs. 21.7±5.7 &2.18± 0.11 respectively in control) p was 0.00 &0.006 respectively. Serum zinc was not significantly different between patients and control (83.7±12 in cases vs 85.3±36.2 in control) ,p was 0.832 .Serum copper was significantly lower in wheezy cases with bronchopneumonia than wheezy cases without (29.5±19.5 vs 55.5±39.5) p was 0.028 ,while zinc was higher in these cases than those cases without (108.2±34.5 vs 67.9±33,8) p was 0.034 .There was no significant difference between wheezy bronchopneumonia and non-infection cases regarding magnesium (2.97±1.2 vs 2.4±0.3) p was 0.232 .Their results prove that possible environmental zinc, copper accumulation in children may play role pathogenesis in infant wheezes ,also proves ant infection role of copper
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