We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of Electrochemical polymerization is appealing because it is cheap, reliable and green (Fonner et al., 2008;Balint et al., 2014); moreover, it is easy to load the polymer with a negatively charged drug (dopant) during the electrochemical polymerization. Hundreds of different anticancer drugs exist of both natural and synthetic origins (Borden et al. 1999;Curt et al.,
H UMAN health may depend on the environment and its compartments, which may include climatic factors. These climatic factors and their changes might impact on human health particularly the outbreak of pandemics like COVID-19. The combined stress resulted from climate changes and COVID-19 could be noticed in several countries especially in the developing countries. Malnutrition is considered one of the most important problems in the developing countries in particular under the droughts, flooding, and other climatic events. Malnutrition was aggravated under COVID-19 outbreak in these countries due to the closure of borders between countries, the crisis of global trade, and the global food insecurity. The biofortification process is the sustainable solution to overcome malnutrition, which included very recently using nano-nutrients as called nano-biofortification. The approach of nanobiofortification is a promising tool in producing biofortified edible plants, otherwise this tool still needs more studies to answer the open questions like which nano-nutrients can be used in nano-biofortification? Which recommended doses and crops are considered suitable candidates?
Background: Ovarian masses present a special diagnostic challenge when imaging findings cannot be categorized into benign or malignant pathology. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) are currently used to evaluate ovarian tumors. Functional imaging by means of diffusion weighted magnetic resonance imaging (DW-MRI) is now part of the standard imaging protocols for evaluation of the female pelvis. DW-MRI is important MR imaging technique which enable the radiologist to move from morphological to functional assessment of diseases of the female pelvis. Aim of the Study: The aim of the current study is to evaluate the diffusion-weighted MR imaging in prediction of the nature of suspicious ovarian masses which are detected previously by conventional ultrasound. Patients and Methods: MRI Unit, radiodiagnosis department, Ain Shams University hospital. The study is prospective, included thirty women who presented with suspicious adnexal masses on previous ultrasound examination and referred for further assessment and characterization by DW-MRI. Patients with contraindications to MRI (e.g. claustrophobia, cardiac prosthesis and metallic plates) are excluded. Results: The study included 30 women ranging in age between 24 and 61 years with mean age 43.22±11.15. Out of 30 cases, 12 had of benign ovarian tumors while 18 had malignant tumors. Conclusion: Thus, combination of DWI and conventional MRI implies using a completely noninvasive technique with no radiation exposure. It is cost effective (no additional cost to MRI examination), and easily added to the MR study protocols with no marked lengthening of examination time. It improves the specificity of MRI and thus increasing radiologist's confidence in image interpretation which will finally reflect on patient's outcome and prognosis.
Background: High-grade gliomas (HGGs) and brain metastases (BMs) can display similar imaging characteristics on conventional MRI. In HGGs, the peritumoral edema is infiltrated by the malignant cells, which was not observed in BMs. Our study aims to determine whether the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values could differentiate HGGs from BMs. Results: Twenty patients with provisional MRI diagnosis of high grade gliomas WHO grade III & IV versus metastatic brain tumors, examination was done on 1.5 tesla scanner, patients were divided into two groups based on pathology results, the fraction anisotropy (FA) was measured in the enhancing tumor parts and immediate peri-tumoral edema. The minimum and mean ADC in the enhancing tumor (ADCmin, ADCmean) and the minimum ADC in the peritumoral region (ADCedema) were measured from ADC maps. Values of FA and ADC measured in the peri-tumoral edema were significantly high in the metastatic than primary high malignant glial tumors, yet no significant differences in the values of FA and ADC measured in the enhancing tumor parts of the two groups. According to ROC curve analysis, a cutoff value of 0.119 for the FA measured in the peri-tumoral edema with sensitivity (100%) and specificity (75%) and a cutoff value of 1.7 x 10-3 for the ADCedema with sensitivity (87.5%) and specificity (75%) generated the best combination of for distinguishing between HGGs and BMs. Conclusion: FA and ADC values were found to distinguish between HGGs and solitary BMs. The peritumoral FA and ADC values are better than the intratumoral FA and ADC values in predicting the tumor type.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.