Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy

Hathout, Rania M.; Metwally, Abdelkader A.; El-Ahmady, Sherweit H.; Metwally, Eman; Ghonim, Noha A.; Bayoumy, Salma A.; Erfan, Tarek; Ashraf, Rosaline; Fadel, Maha; El-Kholy, Abdullah I.; Hardy, John G.

doi:10.1016/j.jddst.2018.07.002

Cited by 33 publications

(17 citation statements)

References 38 publications

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“…To make more specific and effective nanocarrier systems, recently researchers have designed multi-stimuli responsive nanocarriers by combining two or more stimuli-responsive components in a single nanocarrier system [180,181,182]. For example, Jia et al designed a redox/enzyme responsive Figure 11.…”

Section: Dual/multi-stimuli Responsive Nanocarriersmentioning

confidence: 99%

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

Majumder

Minko

2020

Expert Opinion on Drug Delivery

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Introduction: Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to the desired tissues and cells with improved bioavailability, high drug loading capacity, enhanced intracellular delivery, and better therapeutic effect. A specific design of stimuli-responsive nanocarriers allows for changing their structural and physicochemical properties in response to exogenous and endogenous stimuli. These nanocarriers show a promise in site specific controlled release of therapeutics under certain physiological conditions or external stimuli. Areas covered: This review highlights recent progresses on the multifunctional and stimuli-sensitive nanocarriers for targeted therapeutic drug delivery applications. Expert opinion: The progress from single functional to multifunctional nanocarriers has shown tremendous potential for targeted delivery of therapeutics. On our opinion, the future of targeted delivery of drugs, nucleic acids, and other substances belongs to the site-targeted multifunctional and stimulibased nanoparticles with controlled release. Targeting of nanocarriers to the disease site enhance the efficacy of the treatment by delivering more therapeutics specifically to the affected cells and substantially limiting adverse side effects upon healthy organs, tissues, and cells.

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Section: Dual/multi-stimuli Responsive Nanocarriersmentioning

confidence: 99%

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

Majumder

Minko

2020

Expert Opinion on Drug Delivery

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“…By using the electrochemical method, it is also possible to fabricate microelectronic devices by direct deposition of polymeric films in the metal contacts. [54] The remarkable conductive characteristics of PPy make it a suitable polymer as 3D electrode system, [55] electrochemical sensor, [56] nanoparticles (NPs) for anticancer therapy, [57] and antibacterial application. [58]…”

Section: Properties Structure and Applicationsmentioning

confidence: 99%

Conductive Biomaterials as Substrates for Neural Stem Cells Differentiation towards Neuronal Lineage Cells

Farokhi

Mottaghitalab

Saeb

et al. 2020

Macromolecular Bioscience

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The injuries and defects in the central nervous system are the causes of disability and death of an affected person. As of now, there are no clinically available methods to enhance neural structural regeneration and functional recovery of nerve injuries. Recently, some experimental studies claimed that the injuries in brain can be repaired by progenitor or neural stem cells located in the neurogenic sites of adult mammalian brain. Various attempts have been made to construct biomimetic physiological microenvironment for neural stem cells to control their ultimate fate. Conductive materials have been considered as one the best choices for nerve regeneration due to the capacity to mimic the microenvironment of stem cells and regulate the alignment, growth, and differentiation of neural stem cells. The review highlights the use of conductive biomaterials, e.g., polypyrrole, polyaniline, poly(3,4‐ethylenedioxythiophene), multi‐walled carbon nanotubes, single‐wall carbon nanotubes, graphene, and graphite oxide, for controlling the neural stem cells activities in terms of proliferation and neuronal differentiation. The effects of conductive biomaterials in axon elongation and synapse formation for optimal repair of central nervous system injuries are also discussed.

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“…Curcumin has been used in combination with other bioactive agents with good therapeutic outcomes in vitro and in vivo. Furthermore, polymer-based nanocarriers such as nanoparticles [ 13 , 14 , 15 , 16 , 17 ], nanoliposomes [ 18 , 19 , 20 , 21 , 22 ], nanocapsules [ 23 , 24 , 25 , 26 ], nanomicelles [ 27 ], polymer-drug conjugates [ 28 , 29 ], hydrogels [ 30 ], and dendrimers [ 31 , 32 , 33 , 34 ] have been reported for the combination of curcumin and other therapeutic agent(s) for the treatment of cancer [ 35 ]. There are several advantages of employing polymer-based nanocarriers in the treatment of cancer such as reduced drug toxicity, improved cellular uptake and internalization of anticancer drugs, increased drug solubility, improved drug bioavailability and biodegradability, controlled and sustained drug release kinetics, and enhanced patient compliance [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

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Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers to result in promising therapeutic outcomes in cancer treatment. Curcumin exhibits good anticancer activity but its poor bioavailability has resulted in its incorporation into several polymer-based nanocarriers resulting in good biological outcomes. Furthermore, the incorporation of curcumin together with other anticancer drugs have been reported to result in excellent therapeutic outcomes in vivo and in vitro. Due to the potential of polymer-based nanocarriers, this review article will be focused on the design of polymer-based nanocarriers loaded with curcumin together with other anticancer drugs.

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Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy

Cited by 33 publications

References 38 publications

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

Conductive Biomaterials as Substrates for Neural Stem Cells Differentiation towards Neuronal Lineage Cells

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

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