Introduction: Child sexual abuse is an extensive health and societal problem as even the lowest prevalence of child sexual abuse includes a huge number of victims who still need to be considered. Africa has the highest prevalence of child sexual abuse yet still with a paucity of literature on the subject matter. Objective: Describe the epidemiological and clinical profile of children victim of sexual abuse reported at the Yaounde Gynaeco-obstetric and Pediatric Hospital (YGOPH). Methods: A hospital based cross sectional descriptive study was conducted from January 1st, 2017 – December 31st, 2019 at the Yaounde Gynaeco-Obstetric and Pediatric Hospital. Consultation files were examined and identified cases of child sexual abuse (CSA) recruited. Epidemiological and clinical data of included participants were treated using a pre-established questionnaire. Collected data were entered and analysed using SPSS (Statistical Package for Social Sciences) software version 26.0 with p-values calculated following a one variable binomial sampling. Results: In total, data was assessed from 51,331 pediatric consultation files of which 127 cases of child sexual abuse met our inclusion criteria. The prevalence of child sexual abuse was 0.25%. Most victims of child sexual abuse were of the female gender (92%) from single parenting homes (36.8%) (p< 0.05) within two age groups < 5years (32.9%) and 10-15 years (32.9%). Perpetrators were in majority males (84%) of age ≥18 years (72.4%) and were persons known to the victims (73.7%) who proceeded by taking advantage of the victims’ trust. Vaginal penetration (57.9%) with vaginal lesions (59.2%) were the most encountered cases which were placed on highly active anti-retroviral prophylaxis however with poor clinical follow-up (35.5%) as the patients did not turn-up for their visits. Conclusion: Child sexual abuse though not addressed as a matter of urgency, yet it is a problem with a gradual upward trend in our community most especially as perpetrators are persons we are familiar with. Thus, a call for greater vigilance with regards to the guidance we leave our children with.