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Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 jam and 62 jam, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.

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This communication presents the synthesis of N-phenylpiperazines (4), using the organobismuth compound (3) as avlating agent. Triarylbismuthine (3) was obtained by condensation of dty BiCl3 with the orpnolithium intermediate (2).

A reverse‐phase high pressure liquid chromatographic determination of 11 hydroxycoumarins in plant extracts is described, which is applicable to the quantitative analysis of these compounds for industrial purposes. Fraxinus ornus bark from various regions in Bulgaria showed differences both in the total coumarin content and in the relative proportions of each component. The occurrence of 7‐methylesculin and 6,7,8‐trihydroxycoumarin in the family Oleaceae is reported for the first time.

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