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A survey concerning perceptions of academic librarians was conducted at a large, 4-year university with three populations: librarians, faculty, and undergraduate students. The high response rate and the use of an instrument based on previous studies offers the possibility of longitudinal comparison and the identification of relationships between groups within one environment. Results will be presented in a series of articles, beginning with this paper's study introduction and literature review of librarian, faculty, and student perceptions of librarians. Subsequent papers will present results from the three surveys and offer analysis across the three groups. The literature review focused on research studies of U.S. and Canadian academic libraries since 2000 with relevance to these major research questions: perceptions about what librarians know (expertise and skills), what librarians do (role and duties), and what librarians are like (motivations and affective behaviours). Librarians' perceptions of themselves as critically important yet underappreciated seem to have persisted, perhaps because they are the only group to see the university-wide scope of their jobs, whereas, non-librarian faculty and students have a more limited views of the profession. In contrast to previous studies, recent literature suggests that course-integrated information literacy (IL) instruction has increased the visibility of librarians as educators to both faculty and students. The influence of popular media on students' perceptions seems less powerful, opening the door wider for library marketing and branding programs.

This article presents a model of Australian social work with unaccompanied asylum-seeking young people which aims to build hope, agency and meaning for the social worker and the young person. Informed by Foucault's understanding of resistance, the model encourages social workers to pay attention to little practices of freedom through the development of professional relationships which address counselling needs, practical advocacy and social change within complex socio-political, cultural and therapeutic contexts. A case vignette of 'Ali' applies the model in practice. The article concludes with an exploration of the model's potential for international transferability.

Social work practice informed by human rights and trauma frameworks can be empowering and enabling. While both frameworks are complex and contested, their implementation ''from below'' via praxis can maximise benefits for social work with people who have experienced trauma and human rights abuses, such as those from refugee backgrounds. This article presents an exploration of this practice approach through the presentation of the story of Zillah and Amman, a fictionalised composite of many real refugee experiences. Taking as examples the education and child protection systems, the discussion highlights how theory to practice integration requires cross-cultural engagement, critical reflection, dialogue, and an understanding of human rights ''from below''.

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Sjögren’s syndrome is an autoimmune connective tissue disease characterized by dryness of the eyes and mouth and lymphocytic infiltrates in the salivary, lachrymal, and other exocrine glands. Its cause is not known, but the condition may be primary, where the disease exists on its own, or secondary, where it is associated with other rheumatic diseases, most commonly rheumatoid arthritis. It affects women more than men (ratio 9:1) and is the second commonest autoimmune rheumatic disease (after rheumatoid arthritis), but in many patients remains undiagnosed because symptoms are usually mild....

This study aimed to establish the proportion of women seeking information regarding unintended pregnancy in the context of domestic violence (DV) and/or sexual assault (SA) experiences in Queensland. Mental health, sociodemographic variables, and gestation at first and repeated contacts were examined for 6249 women primarily seeking information regarding abortion options during an unintended pregnancy over the five-year period from July 2012 to June 2017. Reports of DV and SA and associations with mental health issues increased significantly across the five years. First contact rates of disclosure were 12.2% for DV and 3% for SA, and higher among repeat contacts (38.1% for DV and 14.1% for SA), with recurring contact facilitating violence disclosure. Restricting access to abortions in the context of violence impedes a woman’s agency in attempts to separate from violence and highlights the need for safe, supportive, and accessible services, to assist in screening and assisting with violence.

High throughput inhibition screens for human cytochrome P450s (CYPs) are being used in preclinical drug metabolism to support drug discovery programs. The versatility of scintillation proximity assay (SPA) technology has enabled the development of a homogeneous high throughput assay for cytochrome P450 2D6 (CYP2D6) inhibition screen using [O-methyl-(14)C]dextromethorphan as substrate. The basis of the assay was the trapping of the O-demethylation product, [(14)C]HCHO, on SPA beads. Enzyme kinetics parameters V(max) and apparent K(m), determined using pooled human liver microsomes and microsomes from baculovirus cells coexpressing human CYP2D6 and NADPH-cytochrome P450 reductase, were 245 pmol [(14)C]HCHO/min/mg protein and 11 microM, and 27 pmol [(14)C]HCHO/min/pmol and 1.6 microM, respectively. In incubations containing either pooled microsomes or recombinant CYP2D6, [(14)C]dextromethorphan O-demethylase activity was inhibited in the presence of quinidine (IC(50) = 1.0 microM and 20 nM, respectively). By comparison, inhibitors selective for other CYP isoforms were relatively weak (IC(50) > 25 microM). In agreement, a selective CYP2D6 inhibitory monoclonal antibody caused greater than 90% inhibition of [(14)C]dextromethorphan O-demethylase activity in human liver microsomes, whereas CYP2C9/19- and CYP3A4/5-selective antibodies elicited a minimal inhibitory effect. SPA-based [(14)C]dextromethorphan O-demethylase activity was also shown to correlate (r(2) = 0.6) with dextromethorphan O-demethylase measured by high-performance liquid chromatography in a bank of human liver microsomes (N = 15 different organ donors). In a series of known CYP2D6 inhibitors/substrates, the SPA-based assay resolved potent inhibitors (IC(50) < 2 microM) from weak inhibitors (IC(50) >or= 20 microM). It is concluded that the SPA-based assay described herein is suitable for CYP2D6 inhibition screening using either native human liver microsomes or cDNA-expressed CYP2D6.