Sjögren’s syndrome

Venables, P. J. W.; Price, Elizabeth

doi:10.1093/med/9780199204854.003.191106_update_001

Cited by 3 publications

(10 citation statements)

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“…SS is the second most common autoimmune rheumatic disease [2], with a prevalence of approximately 1% (range 0.1-4.8%) [2,4] and an incidence of about 7 per 100,000 person-years at risk [5,6]. In total, up to 4 million Americans have SS [7][8][9].…”

Section: Epidemiology Of Ssmentioning

confidence: 99%

“…The dry eye symptoms of SS may include a variety of sensations, including itching, grittiness, and soreness with a normal appearing eye [4,7]. Other ocular symptoms are complaints of eye fatigue, reduced visual acuity, photosensitivity, ocular discharge, erythema, and the sensation of a film across the visual field [7].…”

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

“…Other ocular symptoms are complaints of eye fatigue, reduced visual acuity, photosensitivity, ocular discharge, erythema, and the sensation of a film across the visual field [7]. Patients who previously wore contact lenses may report that they cannot continue to wear them and need to use tear substitutes [4]. Patients may also report accumulation of sticky mucus overnight that makes opening their eyes difficult in the morning [4].…”

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

“…Patients who previously wore contact lenses may report that they cannot continue to wear them and need to use tear substitutes [4]. Patients may also report accumulation of sticky mucus overnight that makes opening their eyes difficult in the morning [4]. The patient's ocular symptoms may be aggravated by various external factors, such as low humidity levels and exposure to cigarette smoke, as well as anticholinergic drugs [7].…”

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

“…On examination, patients with SS can exhibit a variety of ocular findings [4,7]. These include accumulation of mucus secretions along the inner canthus and decreased tear secretion, although there is no correlation between tear flow rates and ocular discomfort.…”

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

See 4 more Smart Citations

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

et al. 2017

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Section: Epidemiology Of Ssmentioning

confidence: 99%

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

Section: Clinical Manifestations Of Ssmentioning

confidence: 99%

See 3 more Smart Citations

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

et al. 2017

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Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome

et al. 2015

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Sjögren's syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands. Despite an ever-increasing focus on identifying the underlying etiology of Sjögren's syndrome, the factors that initiate this autoimmune disease and the mechanisms that cause the subsequent exocrine gland dysfunction remain a mystery. The original explanatory concept for the pathogenesis of Sjögren's syndrome proposed a specific, self-perpetuating, immune-mediated loss of acinar and ductal cells as the principal cause of salivary gland dysfunction. We highlight the possible involvement of regenerating gene (Reg) in the regeneration and destruction of salivary gland acinar and ductal cells in Sjögren's syndrome. The Reg gene was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets and constitutes a growth factor family (Reg family). We describe how salivary gland dysfunction is initiated and maintained and how it can be regenerated or progressed, mediated by the Reg gene, Reg protein, and anti-REG autoantibodies in Sjögren's syndrome. OPEN ACCESSAntibodies 2015, 4 410

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A polymorphic challenge

et al. 2012

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We describe the case of a 19-year-old boy, who presented with diffuse lymph node enlargements and prominent involvement of his parotid glands. After a four-month history of unsuccessful diagnostic investigations, he was finally diagnosed with Kikuchi-Fujimoto's disease (KFD), a rare histiocytosis of unknown aetiology affecting lymph-nodes throughout the body. The diagnosis of KFD can only be made by histopathologic characterization of affected lymph-nodes, while, according to literature, clinical and imaging features can only suggest the presence of such particular disease. Furthermore, as happened in the case of our patient, KFD tends to be hardly distinguishable from lymphoid malignancies and to overlap with other systemic immune-mediated diseases, such as adult onset Still's disease and systemic lupus erythematosus. The significant involvement of intra-parotid lymph-nodes in our patient's case further extended the diagnostic spectrum to include Sjögren's syndrome.

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Sjögren’s syndrome

Cited by 3 publications

References 0 publications

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren’s Syndrome Diagnosis

Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome

A polymorphic challenge

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