Neuroblastoma is a sympathetic nervous system tumor, primarily presenting in children under 6 years of age. The long-term prognosis for patients with high-risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapy. This report provides an update to a phase II trial evaluating DFMO as maintenance therapy in HRNB. Event-free survival (EFS) and overall survival (OS) of 81 subjects with HRNB treated with standard COG induction, consolidation and immunotherapy followed by 2 years of DFMO on the NMTRC003/003b Phase II trial were compared to a historical cohort of 76 HRNB patients treated at Beat Childhood Cancer Research Consortium (BCC) hospitals who were disease-free after completion of standard upfront therapy and did not receive DFMO. The 2-and 5-year EFS were 86.4%
Condition HELP is a unique pediatric patient safety program that gives families an immediate voice in their child's medical care. This patient safety endeavor allows parents to call a telephone number at any time-24 hours a day, 7 days a week-if they feel their hospitalized child's immediate health is endangered. The Condition HELP call receives the same immediate attention as a life-threatening emergency, including deployment of a specialized rapid response team to the child's bedside. This article presents a 2-year analysis of pediatric patient safety outcomes following the implementation of the program.
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