SYNOPSIS As a result of studying the urine proteins of 223 individuals by starch gel electrophoresis, a new urine protein fraction has been recognized. On starch gel electrophoresis at alkaline pH the new fraction moves to a position appreciably nearer the cathode than the slowest-moving y-globulin in normal serum. A small amount of this post-y protein was found in the urine of 46 patients with clinical proteinuria, including 19 with the Fanconi syndrome and nine with multiple myeloma.The nature, origin, and clinical significance of post-y protein is discussed.The proteins that occur in urine have received much less attention than those in serum, probably because the time-consuming step of preliminary concentration is usually necessary for their study. Even so there is a considerable literature dealing with the electrophoresis of urinary proteins in man (Longsworth and
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