The Occurrence of Haemoglobin ‘Bart's’ in Conjunction with Haemoglobin H

Huehns, E. R.; Flynn, F. V.; Butler, Elizabeth A.; Shooter, E. M.

doi:10.1111/j.1365-2141.1960.tb06257.x

Cited by 56 publications

(25 citation statements)

References 20 publications

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“…Hb Dart's associated with haematological abnormalities: In surviving infants Hb Bart's has been found together with Hb D (20), Hb E (25) and Hb S (11). The coexistence of Hb H and Hb Bart's has been noted also in older children and adults (6,10,21). In most of these cases, hypochromic and microcytic anaemia was found.…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin Bart’s and H in a Swedish Boy

Sjölin¹,

Wallenius²,

Wranne³

1964

Acta Haematol

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Section: Discussionmentioning

confidence: 99%

Haemoglobin Bart’s and H in a Swedish Boy

Sjölin¹,

Wallenius²,

Wranne³

1964

Acta Haematol

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“…Studies on cord blood included packed cell volume and hemoglobin levels, as well as the cal culation of the percent nucleated red cells per 100 leukocytes. Hemolysates of thrice-washed cord blood red cells were electrophoresed on starch gel using a Tris-borate buffer, pH 7.7, to look for Hb Barts [5]. Birth weights were recorded to the near est ounce.…”

Section: Methodsmentioning

confidence: 99%

Correlations and Cumulative Frequency Distributions of Maternal and Newborn Hematologic Data

Adams¹

1981

Acta Haematol

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Nonparametric correlation coefficients and cumulative frequency distributions of hematologic data and birth weight obtained from 151 mothers and most of their new-borns have been analyzed. Taken overall, the data reaffirm considerable fetal autonomy in maintaining hematologic homeostasis; a dissociation was found between maternal and newborn hemoglobin (Hb) levels, there was no evidence for an effect of maternal iron deficiency on the fetus, nor was birth weight correlated with maternal Hb levels. However, the lack of significance of the latter two correlations was apparent only when three maternal-newborn pairs with α-thalassemia were excluded from analysis. An inverse relation was found between birth weight and Hb level in the newborn, and this was present over the entire birth weight range, rather than being restricted to small-for-gestational-age newborns.

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“…Haemolysates were prepared with out freezing, in order to minimise loss of Hb-H. Starch gel electrophoretic analyses were made at pH 8.6 in Tris-EDTA-borate buffer, and at pH 6.9 in a phosphate buffer [17]. Published procedures [3,24] were used to detect and estimate small proportions of fetal haemoglobin (Hb-F).…”

Section: Methodsmentioning

confidence: 99%

Occurrence of Haemoglobin H in Leukaemia: a Further Case of Erythroleukaemia

Beaven¹,

Coleman²,

White³

1978

Acta Haematol

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Erythroleukaemia in an elderly Caucasian male was associated with the presence of 15% of haemoglobin H (Hb-H; Hb-β₄) in the haemolysate, identified by electrophoretic analysis, isolation and ‘finger-printing’. The peripheral blood picture was dimorphic, with 40% of hypochromic and morphologically abnormal red cells. Inclusion bodies indicative of the presence of Hb-H occurred in 30% of the red cells after supravital staining. The rare occurrence of Hb-H in leukaemic conditions and its distribution in the red cells is discussed in relation to the possible clonal origin of leukaemia and the involvement of red cell precursors.

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The Occurrence of Haemoglobin ‘Bart's’ in Conjunction with Haemoglobin H

Cited by 56 publications

References 20 publications

Haemoglobin Bart’s and H in a Swedish Boy

Haemoglobin Bart’s and H in a Swedish Boy

Correlations and Cumulative Frequency Distributions of Maternal and Newborn Hematologic Data

Occurrence of Haemoglobin H in Leukaemia: a Further Case of Erythroleukaemia

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