Background: Pomegranates contain chemical saponins and flavonoids while lemongrass stems have flavonoid chemical compounds. Substances that can inhibit the linking of bacteria are saponins and flavonoids. The most common microorganism found in ulcus diabetikum (ulcer diabetes) is Staphylococcus aureus. The purpose of this study was to determine the antibacterial activity of a combination of pomegranate ethanol extract and ethanol extract of lemongrass stems against S. aureus bacteria.Methods: This study used an experimental design with a complete randomized design study divided into 5 groups: groups 1 (75:25), 2 (50:50), 3 (25:75), positive control (tetracycline) and negative control. Manufacture of pomegranate peel extract and lemongrass stems was done by maceration method for further rotary, after the extract was obtained tested for antibacterial activity by diffusion method using a cylinder. With the test used analysis of variance one way.Results: The results of this study showed that the combination of pomegranate ethanol extract and citronella stem ethanol extract showed activity against S. aureus with a ratio of 15 ul:5 ul, 15 ul:15 ul, 5 ul:15 ul with inhibitory diameter of respectively 13 mm, 11 mm, 8 mm. Whereas for positive control with chloramphenicol, the inhibition area is 9 mm.Conclusions: Statistically the combination of pomegranate ethanol extract and lemongrass stems has antibacterial power which uses p=0.005 and p<0.05. The combination of pomegranate ethanol extract and lemongrass stems has very strong antibacterial activity against S. aureus due to inhibition zones of 10-20 mm.
Background: Pomegranate (Punica granatum) is one of the traditional medicines that contains antibacterial compounds that are effective against bacterial growth. Its chemical content includes saponins, tannins and flavonoids. Escherichia coli is a gram-negative bacterium which is a normal flora germ found in the human large intestine. These bacteria are pathogenic when they are outside the intestine and produce enterotoxins in epithelial cells which cause diarrhea. The purpose of this study was to determine the antibacterial effect of pomegranate skin extract on the growth of Escherichia coli.Methods: This study used an experimental design study with a complete randomized design study divided into 5 groups namely groups 1 (15 ug/ml), 2 (20 ug/ml), 3 (25 ug/ml), positive control (ciprofloxatin), negative control. Making pomegranate peel extract was done by maceration method then rotary, after that the effectiveness of pomegranate extract extracted by the diffusion method was tested using Anova one-way test.Results: The results showed that the extract of pomegranate peel showed that it was able to inhibit the growth of Escherichia coli with a ratio of constants (15 ug/ml, 20 ug/ml, 25 ug/ml with inhibition diameters of 6.7 mm, 6.7 mm, 6, 7 mm, while for positive control with ciprofloxatin showed bacterial resistance to antibiotics.Conclusions: Statistically, pomegranate skin extract has an antibacterial power which is meaningful with p 0.005. Pomegranate rind extract has antibacterial activity against Escherichia coli medium because inhibition zone is 5-10 mm.
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