Oral squamous carcinoma cells consistently express MIF independent of their location. Lip tumors presented more MIF-positive peritumoral inflammatory cells, similar to control, suggesting that immunological differences in leukocyte activation exist between in lip and intra-oral cancers.
The chronic usage of nifedipine is associated with the appearance of gingival overgrowth (GO). The frequency of GO associated with chronic nifedipine therapy remains controversial and the possible subclinical effects of this drug on the gingival epithelium should be investigated. We investigated the epithelial proliferation index and apoptosis rate, and their association with epithelial enlargement. Proliferation (Ki67 and Cyclin B1) and apoptosis (BCL2, Bax and p53) markers were identified by immunohistochemistry in twenty-one samples of gingival tissue from patients undergoing chronic treatment with nifedipine and in eleven samples of gingival tissue from healthy patients who did not use drugs associated with GO (control). Our results show that the epithelial tissue of nifedipine users has considerably longer rete pegs compared to control (P = 0.01). However, the density of Ki67(+) and Cyclin B1(+) cells was similar in both groups. Regarding apoptosis, we found more BCL2(+) cells in the nifedipine group when compared to controls (P = 0.12). An increase in Bax(+) cells in the nifedipine group compared to control (P = 0.003) was also seen, and slightly lower levels of p53(+) expression were observed (P = 0.51). Our results suggest that the chronic use of nifedipine is not associated with subclinical changes in gingival tissue.
Conventional spiral tomography plays an important role in pre-surgical treatment planning, increasing clinician's certainty of the need of additional surgical procedures (bone grafting, sinus lifting, and others) in pre-surgical treatment stage.
O diagnóstico precoce de lesões como o adenoma pleomórfico (AP) de glândulas salivares pode ser limitado pela localização profunda e difusa destas glândulas nos tecidos moles da região de cabeça e pescoço. Esta dificuldade agrava-se pelo fato de não se poder estabelecer os limites de tais lesões apenas pelo exame clínico. Das modalidades de exames por imagem, a ressonância magnética (RM) tem demonstrado papel de destaque no diagnóstico do AP por fornecer alta definição dos tecidos moles, sem a utilização de radiação ionizante, sendo uma das mais indicadas para esta finalidade. O objetivo deste estudo foi discutir, por meio de revisão da literatura, a importância dos vários métodos de diagnóstico por imagem, suas vantagens e desvantagens, enfocando a utilização da RM no diagnóstico e plano de tratamento do AP de glândulas salivares. O relato de dois casos ilustra as principais justificativas para a superioridade das imagens por RM no diagnóstico da referida lesão.
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