The resting metabolic rates (RMR) of 60 lean and obese men, aged 18-82 y and weighing 60-171 kg, were measured and body compositions were determined. Body compositional variables reflecting active protoplasmic tissue were all highly interrelated. Body weight alone gave prediction values for RMR that were comparable to those of other variables of active protoplasmic tissue mass. Regional distribution of fat had no influence on the RMR and the influence of age on RMR was trivial. The classic prediction equations and tables overestimate RMR of men. The 95%-confidence limits for both lean and obese men were broad. This conclusively demonstrates that metabolic efficiency is not necessarily or exclusively related to obesity. New regression equations for predicting the RMR based on weight and fat-free mass were developed: RMR = 879 + 10.2 WT kg and RMR = 290 + 22.3 FFMD kg, where FFMD is fat-free mass from densitometry measurements.
Background/Synopsis: While the role of low density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] in predicting coronary heart disease (CHD) and cardiovascular disease (CVD) events is well-established, it is unclear whether Lp(a) remains associated across all levels of LDL-C.Objective/Purpose: We examined in older higher risk adults the relation of these two measures to CHD and CVD events.Methods: The Cardiovascular Health Study is a prospective population-based cohort study of CVD in men and women aged 65 or older (mean age 73.8, 42.4% female). We included 3251 high CVD risk subjects (prior CVD, diabetes or 10-year estimated Framingham CVD risk .20%) with LDL-C, lp(a) and other risk factor measures studied from baseline examinations in 1990-1992 with follow-up through 2011. Cox regression adjusted for risk factors examined the combined relation of LDL-C and Lp(a) categories in relation to future hard CHD (myocardial infarction and CHD death) and CVD events (hard CHD, ischemic stroke, or CVD death).
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