Lipid and Anthropometric Analysis of an Adolescent Population in Iquitos, Peru*

Abstract

Background/Synopsis: While the role of low density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] in predicting coronary heart disease (CHD) and cardiovascular disease (CVD) events is well-established, it is unclear whether Lp(a) remains associated across all levels of LDL-C.Objective/Purpose: We examined in older higher risk adults the relation of these two measures to CHD and CVD events.Methods: The Cardiovascular Health Study is a prospective population-based cohort study of CVD in men and women aged 65 or older (mean age 73.8, 42.4% female). We included 3251 high CVD risk subjects (prior CVD, diabetes or 10-year estimated Framingham CVD risk .20%) with LDL-C, lp(a) and other risk factor measures studied from baseline examinations in 1990-1992 with follow-up through 2011. Cox regression adjusted for risk factors examined the combined relation of LDL-C and Lp(a) categories in relation to future hard CHD (myocardial infarction and CHD death) and CVD events (hard CHD, ischemic stroke, or CVD death).