Cytotoxic T lymphocytes raised against a subdominanl epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumorsPreviously, we have shown that immunization with human papillomavirus (HPV) type 16-derived cytotoxic T lymphocyte (CTL) epitope E7 nned C3 ce3ls and eradicates established O tumors in Bn nude mice, in addition, we show that OTL epitope E7 49-57 is immuno-subdominantJy expressed on C3 cells, inasmuch as CTL raised against C3 cells recognize another naluralK' processed; peptide. The data prestrnled in this study are the first esampJes of CTL-based immunotherapy against established HPVI6-induced tumors, supporting the thought that T cells are involved in the control of cervical cancer. Furthermore, our data stress the feasibility of generating tumor-sp...

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