Patients with OSAS display a regional pattern of right ventricular dysfunction correlated with the severity of disease.

Introduction and backgroundPatients with chronic lung diseases frequently have depressive and anxiety symptoms, but there are very few studies looking at this in patients with bronchiectasis.AimThis study aimed to investigate depression and anxiety and related factors among patients with non-cystic fibrosis bronchiectasis.Patients and methodsThis was a prospective study of 133 patients with bronchiectasis. Patients with confirmed diagnosis of bronchiectasis with high-resolution computed tomography were enrolled in the study. Patients that were clinically stable in the previous 4 weeks were evaluated with the Hospital Depression and Anxiety scale. Symptoms, pulmonary function tests, and medical treatments were recorded.ResultsThe mean age of patients was 49.5±14.5 years (range, 18–77 years), and 81 (60.9%) patients were females. Twenty-eight (21.1%) patients had depression, and 53 (39.8%) had anxiety. Depression score was related to family situation (living with a partner), previous depression history and admission to an emergency department within the last year. Anxiety score was related to female gender, the family situation (living with a partner), previous depression history, and admission to an emergency department within the last year (P<0.05). Depression was positively correlated with hemoptysis, admission to an emergency department within the last year and living with a partner. Anxiety was positively correlated with education level, previous depression history, admission to an emergency department within the last year, and living with a partner.ConclusionPatients with non-cystic fibrosis bronchiectasis are at increased risk for depression and anxiety. Untreated and undetected depressive/anxiety symptoms may increase physical disability, morbidity, and health care utilization. It is important for clinicians to be aware of the presence of depression and anxiety in bronchiectasis.

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Background/aim: We evaluated patients with cryptogenic organizing pneumonia (COP) who attended our clinic. Materials and methods:We retrospectively investigated the clinical and radiological findings, diagnostic methods, treatment, and follow-up outcomes of 17 patients who had been histopathologically diagnosed with COP. Results:The mean age of the patients was 49.8 ± 10.4 years. The most common symptom was cough (n = 15; 88.2%) and the most common radiological finding (n = 10) was consolidation in the inferior lobes on thoracic computed tomography. The diagnosis of COP was made by open lung biopsy in 11 (64.7%) patients, transbronchial biopsy in 5 (29.4%), and video-assisted thoracoscopic surgery biopsy in 1 (5.9%). The mean follow-up period was 28.7 ± 25.0 (range: 3-85) months. Twelve patients received oral corticosteroid therapy and seven of them improved without any fibrotic changes. One patient refused treatment; a chest radiography of that patient was found to be normal at the end of the 20-month follow-up period. Three patients received no other therapy, as the lesion had been completely excised. Conclusion:Common symptoms included cough and dyspnea, while the main radiological presentation of COP was consolidation. Corticosteroids are a good treatment option in general, but relapse may occur.

ÖZETAmaç: Obstrüktif uyku apnesi sendromu (OSA) solunumla ilgili uyku bozuklukları içinde incelenen ve vücuttaki birçok sistemi ilgilendiren önemli bir sağlık sorunudur. Koroner arter hastalığı için asemptomatik olup, OSA varlığından şüphe edilen hastalar kullanılarak yapılan bu kesitsel gözlem çalışması, obstrüktif uyku apnesi sendromu ile koroner ateroskleroz varlığı ve yaygınlığı arasındaki ilişkiyi doğrudan araştırmak için planlanmıştır. Yöntemler: Çeşitli nedenler ile uyku laboratuvarında uyku testi yapılan 97 hastaya (yaş: 49.17±0.86) tomografik koroner kalsiyum skorlaması tetkiki yapıldı. Tüm hastaların kardiyovasküler risk faktörleri, kullanmakta oldukları ilaçlar ile uyku testi sonuçları kaydedildi. Hastalar uyku testinde saptanan apne-hipopne indeksleri (AHİ) kullanılarak obstrüktif uyku apnesi şiddetine göre 4 gruba ayrıldı. Değişkenler arasında ilişkile-rin değerlendirilmesinde lineer ve lojistik regresyon analizleri kullanıldı. Bulgular: Gruplar arasında basit horlama grubundan ağır OUAS grubuna gidildikçe tomografik koroner kalsiyum skorlaması ile öngörülen kardiyovasküler risk skorlarının doğrusal olarak anlamlı derecede arttığı görüldü (p=0.046). Hastalar cinsiyete göre ayrıldıklarında, AHİ ve uyku ABSTRACT Objective: This cross-sectional observational study is designed to evaluate direct effects of obstructive sleep apnea syndrome (OSA) on presence and extent of coronary atherosclerosis by using tomographic coronary calcification scoring on a population asymptomatic for coronary artery disease. Methods: Ninety-seven consecutive patients (49.17±0.86 years) who were evaluated with sleep study for the suspicion of obstructive sleep apnea syndrome underwent tomographic coronary calcium scoring test. Cardiovascular risk factors, current medications and sleep study recordings of all patients were recorded. Patients were classified into 4 groups according to the apnea-hypopnea index (AHI). Linear and logistic regression analyses were used for assessment of association between variables. Results: Coronary risk scores of patients, assessed by tomographic coronary calcium scoring, were observed to increase linearly from simple snoring group to severe OSA groups (p=0.046). When patients were classified according to their gender, AHI and parameters reflecting severity of OSA-related hypoxia were found to correlate significantly with coronary risk scores of women but not with scores of men. Linear regression analysis revealed age as the only independent associated variable with cardiovascular risk scores assessed by tomographic coronary calcification scoring (Beta coefficient: 0.27, 95% CI 0.007-0.087, p=0.018). Binary logistic regression analysis also revealed age as the only variable which independently predicted the presence of coronary calcification (OR:1.11, 95% CI 1.039-1.188, p=0.002). Conclusion: These results suggest that presence of OSA may contribute to coronary artery disease risk of patients in association with its severity; however, association between OSA and subclinical atherosclerosis seems ...