Accidents, the majority of which can be prevented, are a significant cause of morbidity and mortality in children. In the 0-6 years age group, in particular, the vast majority of accidents occur in the home or surroundings. Therefore, the knowledge and awareness of mothers are of great importance in the prevention of accidents. The aim of this study was to investigate the frequency, type, and risk factors of home accidents in children aged 0-6 years, and to determine the precautions taken against home accidents by the mothers.

HD is a significant condition that should be treated appropriately to avoid serious complications.

This previously unreported c.532C>A /p.Arg178Ser heterozygous de novo mutation in the ACTG2 gene may lead to a severe form of MMIHS.

Studies describing paediatric sleep patterns are needed by taking culture into consideration. The aim of this study was to identify parent-reported sleep-wake patterns in young children and explore possible factors influencing sleep problems. The mothers of 2,434 young children enrolled from well-child outpatient

No abstract

Iron overload in β-thalassemia major and intermedia patients leads to oxidative stress and causes to formation of lipid hydroperoxides. Thiobarbituric acid reactive substances (TBARS) are a well established method for screening and monitoring of lipid peroxidation. We aimed to investigate serum TBARS and its relationship with biochemical and hematologic parameters of Turkish and immigrant Syrian β-thalassemia children reflecting the effects of this socioeconomic condition on follow up of these patients. Lipid peroxidation products (TBARS) of Turkish (TR) (n = 62, from the cities of Gaziantep and Sivas, Turkey) and Syrian (SYR) (n = 34, from Gaziantep, Turkey) β-thalassemia patients aged 2-17 years and 58 healthy subjects aged 2-16 years were studied. Liver and renal function tests, serum ferritin levels, white blood cell, absolute neutrophil and platelet counts, hemoglobin (Hb) levels of the patients were analyzed. Serum TBARS concentrations were found to be elevated in β-thalassemia patients compared to healthy subjects (mean: 12.47 ± 8.53 vs. 9.78 ± 7.09, = 0.045). In SYR patients mean pretransfusional Hb level (7.26.2.04 vs. 8.49 ± 1.01, = 0.002) was lower and ferritin levels (5983.56 ± 5065.56 vs. 3234.60 ± 2237.82, = 0.001), liver enzymes (ALT: 77.82 ± 76.48 vs. 42.13 ± 51.50, = 0.005) were higher when compared to TR group. Positive correlation between TBARS and ferritin levels ( = 0.029, r = 0.231) and liver enzymes (for ALT < 0.001, r = 0.373) was observed. β-thalassemia patients are under more oxidative stress than healthy subjects. Liver is one of the major organs which are mainly affected by oxidative stress. War and migration might have caused inappropriate transfusion conditions and insufficient chelation therapy in the SYR group.

Amaç: Bu çalışmada Çocuk Polikliniği'ne başvuran çocuklarda enürezisle ilişkili sosyodemografik faktörlerin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Enürezisli çocukların (n=131) aileleri ile yapılan görüşmelerden elde edilen veriler değerlendirildi. Olgular cinsiyet, başvuru yaşları, ailede enürezis öyküsü, eşlik eden hastalık, uyku derinliği ve tedavi yöntemi ile sosyoekonomik açıdan ailenin gelir düzeyine göre incelendi. Bulgular: Olguların 86'sı (%65.6) erkek, 45'i (%34.4) kızdı. Başvuru yaşı açısından her iki cins arasında anlamlı bir fark yoktu. Otuz dört (%35.1) olguda ikincil enürezis mevcuttu. Olguların 23'ünün (%11.3) sadece annesinde, 37'sinin (%32.2) sadece babasında, yedisinin (%3.6) her iki ebeveynde, 44'ünün (%22.8) kardeşlerinde ve 67'sinin (%34.7) diğer akrabalarında pozitif enürezis öyküsü saptandı. Başvuru öncesi 22 olguya (%16.7) ilaçla tedavi, beş olguya (%3.8) ise su kısıtlama tedavisi uygulanmıştı. Eşlik eden hastalık açısından değerlendirildiğinde 4 (%3.05) olguda spina bifida, 15'inde (%11.4) konstipasyon, 31'inde (%23.7) geçirilmiş idrar yolu enfeksiyonu öyküsü ve 3'ünde (%2.2) vezikoüreteral reflü saptandı. Sonuç: Enürezisli çocuklarda eşlik edebilecek organik sorunlar nedeniyle her olgu sistematik biçimde değerlendirilmelidir. Ailelerin enürezisin tedavi edilebilir bir hastalık olduğu konusunda bilgilendirilmesi, tanı alan olguların uygun yöntemlerle erken dönemde tedavi edilmesi önemlidir.

Severe congenital neutropenia type 4 is a disorder of the hematopoietic system associated with mutations in the glucose-6-phosphatase catabolic 3 (G6PC3) gene. This disorder is characterized by neutropenia, congenital heart defects, urogenital malformations, and prominent superficial veins. To our knowledge, although intermittent thrombocytopenia is observed in this mutation, the coexistence of large thrombocytes is rarely seen. Here we present a case of severe congenital neutropenia type 4 with G6PC3 mutation and large platelets in the peripheral smear.