Objective: Uterine perfusion, particularly the endometrial blood flow, may have an important role in endometrial receptivity. In order to assess the contribution of sub endometrial blood flow in the etiopathogenesis of unexplained infertility mid luteal-peri-implantation period spiral artery transvaginal color Doppler parameters were measured and compared with fertile controls. Material and Methods: Forty-two consecutive patients admitted toIzmir Katip Celebi University Ataturk Training and Research Hospital, Department of Obstetric and Gynecology with the diagnosis of unexplained infertility after standard diagnostic work up constituted the study group and they were compared with a fertile control group admitted to hospital with non specific gynecological complaints or for check-up in the same period. Mid luteal transvaginal color Doppler ultrasonography was applied to each patient by the same radiologist who was blind to the diagnosis of the particular patient and, RI (resistance index) and PI (pulsatility index) values were calculated.Results: There were no significant differences between the two groups, in respect to age, body mass index, basal hormonal and mid luteal progesterone levels (p>0.05). For the fertile control group, mid luteal-peri-implantation phase endometrial spiral artery mean RI values were calculated as 0.48±0.08 SD and mean PI values as 0.65±0.18 SD. For the study group, mean RI values were calculated as 0.54±0.07 SD, PI values were calculated as 0.80±0.16 SD. The differences for RI (p=0.009) and PI (p=0.004) were statistically significant. Conclusion:According to Doppler parameters, unexplained infertility patients have high impedance blood flow in spiral arteries which means that peri-implantation blood flow in these patient is lower than fertile controls. These findings suggest that endometrial perfusion may have an important contribution to etiopathogenesis of unexplained infertility. (J Turkish-German Gynecol Assoc 2012; 13: 169-71) Key words: Unexplained infertility, endometrial blood flow, endometrial receptivity, transvaginal ultrasonograhy, colored Doppler Received: 13 June, 2012 Accepted: 21 July, 2012 Amaç: Endometrial kan akımının, endometrial implantasyonda önemli rol oynadığı düşünülmektedir. Biz çalışmamızda subendometrial kan akımının açıklanamayan infertilitedeki önemini belirleyebilmek için mid-luteal-periimplantasyon dönemindeki kan akımını TVUSG doppler ile ölçerek fertil kontrol grubu ile karşılaş-tırdık. Gereç ve Yöntemler: Çalışmamıza İzmir Katip Çelebi ÜniversitesiAtatürk Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği'ne infertilite nedeni ile başvurmuş ve yapılan tetkikler sonucunda açıklanamayan infertilite olarak tanı almış 42 hasta ile fertilite dışındaki jinekolojik şikayetler ile başvurmuş fertil hastaların midluteal dönemindeki endometrial kan akımı değerlendirildi. Ölçüm-ler; rezistans indeksi ve pulsatilite indeksi, hastaların hangi gruba ait olduğunu bilmeyen tek radyolog tarafından yapıldı. Abstract ÖzetOriginal Investigation ...

Background: The present study aimed to determine genetic diversity of Trichomonas vaginalis (T. vaginalis) isolates with microsatellite markers in Turkey (Nov 2015 to 2016) and to create a web-based microsatellite typing (MT) approach for the global interpretation of the data. In addition, the endosymbiosis of Mycoplasma hominis (M. hominis) and T. vaginalis virus (TVV) in the isolates was also examined. Methods: The allele sizes for each locus were calculated and microsatellite types were determined according to the allele profiles. The population structure was examined with Bayesian clustering method. A website (http://mttype.adu.edu.tr) was created for collection and sharing of microsatellite data. Presence of TVV and M. hominis in T. vaginalis isolates were investigated with electrophoresis and PCR. Results: Of 630 vaginal samples T. vaginalis was detected in 30 (4.7%) and those were used for further analysis. The structure produced by a clustering algorithm revealed eight genetic groups. The typing of isolates according to microsatellites revealed 23 different microsatellite types. Three clones were determined among isolates (MT10 16.7%; MT18 10% and MT3 6.7%). The frequency of TVV and M. hominis was 16.6% (n=5) and 20% (n=6), respectively. Conclusion: Presence of three clones among 30 T. vaginalis isolates indicated that microsatellite-based genotyping was efficient to determine the clonal distribution of T. vaginalis isolates. Therefore, a promising tool might be developed further and adapted to the studies dealing with molecular epidemiology of T. vaginalis. Microsatellite data from forthcoming studies will be deposited and presented on the website. In addition, we also presented the frequency of two endosymbionts in T. vaginalis isolates for the first time in Turkey

Birçok farklı mekanizmanın öne sürülmesine rağmen, preeklampsinin patogenezi halen tam olarak anlaşılamamıştır. Adrenomedullin kan basıncı regulasyonuna katkıda bulunan güçlü vasodilatör ve natriüretik bir peptid olup hipertansif hastalıklar ile ilişkilidir. Buna karşın bu peptidin preeklampsiyle ilişkisi hakkındaki veriler farklılık göstermektedir. Bu çalışmada biz maternal serum adrenomedullin konsantrasyonlarının preeklamptik gebeliklerde artış gösterip göstermediğini değerlendirmeyi amaçladık.

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