Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Uysal, Selda; Özbay, Elif Pelin Özün; Ekinci, Tekin; Aksüt, Hayri; Karasu, Şebnem; Işık, Ahmet Zeki; Soylu, Ferit

doi:10.5152/jtgga.2012.22

Cited by 22 publications

(24 citation statements)

References 15 publications

(20 reference statements)

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“…The study affirms [5,2] that the E thickness and its structure, as well as its adequate vascularization are useful prognostic factors in relation to ET success in IVF cycles. The data on the minimal E thickness for a successful pregnancy vary in the literature.…”

Section: Discussionsupporting

confidence: 75%

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Predicting of successful implantation at IVF cycles

Devyatova¹,

Цатурова²,

Vartanyan

2016

Gynecological Endocrinology

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Many of the uterine infertility factors are associated with chronic endometritis. Its prevalence reaches 92.6%. Quality of endometrial transformation during the "implantation window" is the basis of successful fertility. In our retrospective comparative study of 101 in vitro fertilization (IVF) cycles, the efficacy of transvaginal Doppler ultrasound (TVDUS) in predicting successful implantation was evaluated. Inclusion criteria were as follows: age younger than 41 years and good quality of embryos. Exclusion criteria were as follows: 41 and older age, poor quality of embryos and uterine cavity lesions. The 1st group included 38 cases with the presence of endometrial blood flow (EBF). The 2nd group included 63 cases with the absence of EBF. TVDUS was performed before embryo transfer (ET). Significant differences of EBF were connected with age and duration of infertility. In women of less than 31 years old, EBF was detected in 47.4% cases versus 26.3% women of older age. EBF was not detected in 74.6% of the cases of duration of infertility for 5 years and more. Pregnancy rate was significantly higher in the 1st group (63.1% versus 39.7%) and when endometrial thickness was 8-11 mm (52.1% versus 30.0%). We offer routine evaluation of endometrial thickness and EBF with TVDUS as a very helpful approach for predicting the implantation in IVF cycles.

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Section: Discussionsupporting

confidence: 75%

“…), and the birthrate has not changed significantly [1]. Infertility prevalence is between 10 and 15% in the general population [2,3]. Its treatment by IVF is becoming increasingly popular in Russia.…”

Section: Introductionmentioning

confidence: 99%

Predicting of successful implantation at IVF cycles

Devyatova¹,

Цатурова²,

Vartanyan

2016

Gynecological Endocrinology

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“…Battaglia et al 39 reported the highest pregnancy rate in the group with lower resistance to blood flow in the uterine spi¬ral arteries. This finding revealing that the decrease in peripheral impedance in the uterine vasculature was considered to be a consequence of increased blood flow and a sign of high tissue perfusion, and this might be an important prerequisite for successful invitro fertilization and embryo transfer cycle (40) . With endometrial thickness less than 8 mm and no-tripleline pattern on hCG day in IVF/ICSI cycles, and high RI there is a poor chance of achieving pregnancy.…”

Section: Such Finding Coincided With Silverberg Et Almentioning

confidence: 88%

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

2017

Evidence Based Women's Health Journal

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Background: Hormone levels (progesterone "P" and luteinizing hormone "LH) are vitally important to the proper functioning of the female reproductive cycle and together with Ultrasound assessment of endometrial receptivity may predict success of in vitro fertilization/ intracytoplasmatic sperm injection (IVF/ICSI). Objective: to study the effects of serum P and LH levels together with Ultrasound assessment of endometrial receptivity at the day of human chorionic gonadotrophin administration on fertilization and pregnancy rates. Patients and Methods: Thirty patients age ranged 22-38 years underwent ovarian stimulation using a gonadotrophinreleasing hormone (GnRH) agonist for pituitary down-regulation, and then ovarian hyperstimulation was initiated with highly purified human menopausal gonadotrophin (HMG). Final oocyte maturation was triggered 36 hours after human chorionic gonadotrophin (hCG) injection. On the day of hCG administration (Day 0), serum progesterone, LH levels together with Ultrasound assessment of endometrial receptivity (thickness, morphology and the spiral artery resistance index "RI") were evaluated. Fertilization and pregnancy rates were recorded. Results: There was no significant difference between the pregnant and non pregnant women, in respect to age. The pregnancy rate was not affected by the serum LH level but was only 18.75% in cycles in which serum P was more than 1.2 ng/ml on day 0, which was significantly lower than that in cycles in which serum P was less than 1.2 ng/ml on day 0 (64.28%) (P = 0.001). The fertilization rate was lower in the cycles with higher levels of serum P and/or LH than in cycles in which serum P was less than 1.2 ng/ml and serum LH was normal (51.66 vs. 68.85%). Failed cases had altered endometrium and a higher spiral artery RI (resistance index), meaning lower peri-implantation blood flow. Conclusion: This study concluded that the progesterone levels on the day of hCG administration (Day 0) can affect the success of in vitro fertilization, as higher progesterone levels were associated with lower rates of pregnancy and fertilization. Increase serum P level caused advanced endometrial maturation and impaired endometrial receptivity to embryo implantation. The embryo transfer (ET) in such cases can be canceled and freezing all embryos for future transfer must be considered, to increase acceptance of the endometrium and thus increase the success rate.

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“…The endometrial blood flow as shown by the spiral artery may have an important role in endometrial receptivity. Accordingly, in a study, both pulsatility and resistance indexes of the spiral artery were found to be significantly higher in the infertile study group than in the fertile control group (12). Also, the spiral artery S/D ratio was lower in the patients who had a pregnancy compared to those who did not …”

Section: Behçet's Disease Patients' Disease Featuresmentioning

confidence: 91%

Color Doppler analysis of female reproductive vasculature in Behçet’s disease

et al. 2016

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summaryBehçet's disease (BD) may affect female reproductive vasculature. We aimed to evaluate Doppler sonographic characteristics of female reproductive vasculature and also ovarian volume, endometrial thickness (EMT) and antral follicle count of BD patients in comparison with a healthy control group. Seventeen premenopausal women aged between 18-45 years with BD, and a control group of 31 age-and body mass index-matched healthy women was included in the study. Uterine, spiral and intraovarian artery blood flow were examined by Doppler sonography in the late follicular phase. Resistance index, pulsatility index and systolic/diastolic ratio were recorded together with ovarian volume, EMT and antral follicle count. In particular this is a pilot study including the evaluation of the spiral and uterine arteries in BD. Doppler sonographic parameters, ovarian volume, EMT and antral follicle count of BD patients and healthy controls were not found to be statistically different. As a result of our analysis, we found similar Doppler sonographic features of both BD patients and the control group. Further studies conducted on a larger sample population with more aggressive BD symptoms may reveal the actual effect of BD on the female reproductive system.

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Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Cited by 22 publications

References 15 publications

Predicting of successful implantation at IVF cycles

Predicting of successful implantation at IVF cycles

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

Color Doppler analysis of female reproductive vasculature in Behçet’s disease

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