Sublethal effects of copper pyrithione (CuPT) on an invertebrate model
organism, freshwater mussel (Unio mancus), were assessed using oxidative
stress parameters and histopathology. The environmentally relevant
concentration of 5 ?g/l copper pyrithione was applied as a 96 h semi-static
exposure. MDA levels in digestive gland (DG) significantly increased,
compared to a control group (p < 0.001). Gill MDA levels also increased, but
not significantly (p > 0.05). GSH level in DG increased significantly (p <
0.05), and gill tissue levels also increased but not significantly (p >
0.05). Levels of SOD, GPx activities, and AOPP levels did not change
significantly (p > 0.05). The most prominent histopathological alterations
in the gills were haemocyte infiltration, lipofuscin aggregates and lamellar
deformations with tubule degeneration and accumulated lipofuscin aggregates
in DG tubules. CuPT impacts antioxidant defense systems even during
sublethal exposure of Unio mancus as the freshwater model organism.
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