Although several other studies have demonstrated the overall analgesic superiority of ibuprofen to acetaminophen, this study demonstrated that the liquigel formulation also provides a clinically relevant advantage for time to analgesic effects.
THE body temperature decreasing effect of histamine in dogs and guinea-pigs was first described by Dale and Laidlawl. Similar results with regard to rats were observed by several authors ; Gyermek2 described that this effect increased as the environmental temperature decreased. In contrast, Leschke3 and Smith4 reported that histamine had no temperature lowering effect on rabbits. That antihistamines also exert a body temperature decreasing effect was reported by Ambrus, Ambrus, Jacob and H a m~s o n~~~~~~* , who described such effect on mice, rats and guinea-pigs. Halpern and Briotg compared the temperature decreasing effect of 6 different antihistamines in rats, and stated that a parallelism exists between antihistaminic activity and temperature lowering effect. Ambrus, et al.lO, described antagonism between the body temperature lowering effect of certain doses of histamine and antihistamines in mice; above and below this optimal dose range, however, synergism occurred. In guinea-pigs and rats5p6 small doses of antihistamines (which in themselves did not affect body temperature) prevented the hypothermic action of histamine.This study was designed to further investigate the above phenomena ; specially to examine the effect of histamine and antihistamines on the body temperature of different species and to study the parallelism between antihistamic activity and temperature lowering effect, employing a broader spectrum of antihistamines.
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