Effect of Enzyme‐Toothpastes upon Oral Hygiene

Harrisson, Joseph W.E.; Salisbury, G. B.; Abbott, D.D.; Packman, Elias W.

doi:10.1902/jop.1963.34.4.334

Cited by 27 publications

(11 citation statements)

References 2 publications

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“…Early clinical evidence in the 1960s demonstrated that a highly proteolytic mixture of enzymes of fungal origin formulated into toothpaste was effective at reducing extrinsic stain compared to a negative control toothpaste after 6 months of product use. 81 More recently, a toothpaste containing a mixture of the protease enzyme papain, alumina and sodium citrate has been described in the literature. Although an early clinical study showed no significant effect of this toothpaste on removing established extrinsic stain versus a placebo toothpaste, 82 further clinical studies have demonstrated the combination toothpaste to be effective at removing established stains, 83 more effective at removing established extrinsic stain than a tartar control toothpaste, 84 and more effective at removing chlorhexidine induced stain than a control toothpaste.…”

Section: Abrasivesmentioning

confidence: 99%

Whitening toothpastes: A review of the literature

Joiner

2010

Journal of Dentistry

224

261

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Section: Abrasivesmentioning

confidence: 99%

Whitening toothpastes: A review of the literature

Joiner

2010

Journal of Dentistry

224

261

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“…investigated the effect of enzyme chewing gums upon oral hygiene. They compared dehydrated pancreas to combined enzymes of fungaj origin and found the latter to be superior in retarding calculus formation, Harrison et al, (1963) used various fungal enzymes in toothpastes and found them to be effective during the 6-month study in retarding the deposition of hard and soft accretions on the tooth. The results indicated that highly proteolytic activity of specific types is more beneficial in retarding these deposits than a high amylolytic or cellulase enzyme mixture.…”

Section: Enzymesmentioning

confidence: 99%

Chemical inhibition of Plaque

Hull

1980

J Clinic Periodontology

161

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Attempts to control plaque by chemical means using enzymes, antibiotics and antiseptics are reviewed. Enzymes such as mucinase, dehydrated pancreas, enzymes of fungal origin, dextranase and mutanase showed limited clinical success despite promising in vitro and animal studies. Side effects from the use of enzymes were observed. Many antibiotics have been used in attempts to control plaque and several have been successful. However, problems exist from the long-term use of such drugs which precludes their routine use as agents for controlling plaque. The biguanide chlorhexidine is the most widely used and investigated method of chemical plaque control. Many studies have been demonstrated that it will successfully control plaque. No toxic side effects have been reported from its long-term use but local side effects such as staining of the teeth do occur. The quaternary ammonium compounds have at present no advantages over the biguanides and require more frequent usage to achieve the same degree of plaque control as chlorhexidine.

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“…Early clinical evidence demonstrated that a highly proteolytic mixture of enzymes of fungal origin formulated into toothpaste were effective at reducing extrinsic stain levels as compared to a negative control toothpaste after 6-months of use. [6] Clinical studies have demonstrated the stain removal efficacy of dentifrice containing papain, alumina and sodium citrate. [7–9] Recently an in vitro study reported that a papain and bromelain (proteolytic enzymes) containing dentifrice was more effective in removing stains than the control dentifrice.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Extrinsic Stain Removal by Novel Dentifrice Containing Papain and Bromelain Extracts

Pentapati¹,

Acharya²

2012

Journal of Young Pharmacists

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To evaluate the stain removal efficacy of a novel dentifrice containing papain and bromelain extracts (Glodent) in comparison with a control dentifrice (Colgate regular). This was a randomized, positive-controlled, double-blinded, clinical study. Subjects were randomly divided into one of the two study groups. Pre-treatment and post treatment photographs of the 4 anterior teeth were recorded under standardized conditions and analyzed for lightness or luminosity values using Adobe Photoshop. The difference between the mean pre-treatment luminosity of test and control groups was not statistically significant. In both test and control groups, the post-treatment luminosity was significantly higher than pre- treatment luminosity (P < 0.001 and P = 0.003 respectively). The mean post-treatment luminosity for test group was found to be significantly higher than control group. The mean percentage removal of stains for test group was significantly higher than control group. The test dentifrice showed significant stain removal when compared to control which could be attributed to the role of proteolytic enzymes in the test dentifrice.

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Effect of Enzyme‐Toothpastes upon Oral Hygiene

Cited by 27 publications

References 2 publications

Whitening toothpastes: A review of the literature

Whitening toothpastes: A review of the literature

Chemical inhibition of Plaque

Efficacy of Extrinsic Stain Removal by Novel Dentifrice Containing Papain and Bromelain Extracts

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