Background: Diabetes mellitus (DM) is known as a worldwide growing metabolic disorder which reduces fertility. Objectives: The objective of the present study was to evaluate the effect of alcoholic root extract of Anacyclus pyrethrum (AP) on FSH, LH, testosterone and sperm count in diabetic male rats. Methods: This study was conducted on 60 Wistar-Albino male rats divided into six groups: control group (C), and diabetic groups including: control group (DC), placebo receiver (P) which received 50 (DA1), 100 (DA2) and 150 (DA3) mg/kg alcoholic AP root extract during trial period. Diabetes was induced with an intraperitoneal injection of streptozotocin (STZ, 60mg/kg). At the end, animals were anesthetized and blood samples were collected from cervical vessels. Serum FSH and LH were determined by ELISA methods. Serum testosterone was measured by standard laboratory method. Sperm count in epididymis and vas deferens was determined using a hemocytometer. The data were analyzed using SPSS V.11 via ANOVA and Tukey tests. Results were expressed as mean ± SD.Statistical differences were considered significant at P < 0.05. Results: Results showed that the serum FSH, LH, testosterone, epididymis, testis, and body weight in all groups which received AP alcoholic root extract significantly increased compared to groups DC and P. Conclusions: AP alcoholic root extract improved FSH, LH and testosterone hormones and body weight gain in STZ diabetic male rats.
The effects of zinc sulfate supplementation on serum copeptin, c-reactive protein and metabolic markers in zincdeficient diabetic patients on hemodialysis: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research.
Background: Artemisia are various groups of plants which are used as an herbal medicine in all countries; the present study was designed to evaluate the effects of Artemisia dracunculus (AD) leaves aqueous extract on blood sugar, serum insulin, and triglyceride and liver enzymes in Fructose Drinking water (FDW) male rats.
Background and Objectives: Capparis decidua is a plant used in herbal medicine. This study was carried out to assess effects of C. decidua hydroalcoholic extract on blood glucose, lipid profile and leptin in male rats with high-cholesterol diets. Materials and Methods: Totally, 40 Wistar-albino male rats with 200-250 g weight were equally divided into one control (C) and three experimental groups of high-cholesterol diet (HCD), high-cholesterol diet and lovastatin (HCDL) and high-cholesterol diet and C. decidua hydroalcoholic extract (HCDCD). At the end of the intervention, animals were sacrificed using deep anesthesia. Blood samples were collected and fasting blood sugar (FBS), high density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG) and leptin were assessed. Low density lipoprotein (LDL) was calculated using Friedewald formula. Results were expressed as mean ±SE (standard error). The P<0.05 was considered as statistically significant. Results: Serum TG in HCDCD group significantly decreased, compared to C and HCD groups (71.33±3.55 (mg dl-1) instead of 97.55±7.09 (mg dl-1) and 94 ±7.01(mg dl-1) respectively, P=0.003) and TC in HCDCD group significantly decreased, compared to HCD group (67.66±2.65 (mg dl-1) instead of 83.11±5.25 (mg dl-1), P=0.021). Moreover, TC in HCDL group significantly decreased, compared to HCD group (68.33 ±1.88 (mg dl-1) instead of 83.11 ±5.25 (mg dl-1), P = 0.04). Leptin included the lowest value in HCDL group, compared to other groups (P<0.0001). Other parameters did not include significant differences within the groups. Conclusions: The current findings have demonstrated that hydroalcoholic extracts from C. decidua leaves and thin stems decreased serum TG and TC in HCDCD male rats.
Introduction
Chronic kidney disease (CKD) is a growing global health problem. Recently, an epidemic of CKD of unknown origin (CKDu), a form of CKD seen mostly in agricultural communities, has been emerged. One of the proposed causes of CKDu is pesticide use in farmers. On the other hand, the research on relation between indoor use of pesticides and CKDu is little. In this study, we aimed to investigate the association between indoor use of pesticide as well as the exposure time with CKDu. This study was done as part of the population-based cohort of Prospective Epidemiological Research Studies in Iran. We used the baseline data of the Zahedan Adult Cohort Study. All subjects with diabetes mellitus and/or hypertension, estimated glomerular filtration rate (eGFR) between 60–89 ml/min/1.73 m2, and unavailable creatinine measurement were excluded. Subjects with an eGFR of less than 60 ml/min/1.73 m2 were defined as having CKDu, and their data were compared with those with an eGFR of more than 90 ml/min/1.73 m2. Data regarding indoor pesticide use and duration of exposure were obtained through a questionnaire. After applying the exclusion criteria, 1079 subjects remained in the study. Female sex, single marital status, low physical activity, triglyceride (TG) levels of more than 150 mg/dl, body mass index (BMI) of more than 25 kg/m2, non-smokers, indoor pesticide use, and high pesticide exposure time were associated with CKDu. The effects of age, female sex, TG levels more than 150 mg/dl, pesticide use (OR 1.36; 95% CI 1.01–1.84), and high exposure time (third tertile of exposure time) compared to non-users (OR 1.64; 95% CI 1.07–2.51) remained significant in multivariable analysis.
Conclusion
We found a positive association between pesticide use, as well as longer exposure time to pesticides, and impaired kidney function in cases without diabetes mellitus and hypertension. Further longitudinal studies should be carried out to confirm these findings.
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