The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial

Hosseini, Razieh; Montazerifar, Farzaneh; Shahraki, Elham; Karajibani, Mansour; Mokhtari, Ali Mohammad; Dashipour, Alireza; Jalali, Mohammad

doi:10.1007/s12011-021-02649-7

Cited by 11 publications

(6 citation statements)

References 42 publications

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“…Zn deficiency is a predictor of cardiovascular death in dialysis patients [ 166 ], and decrease of Zn levels in dialysis patients is significantly correlated with diastolic dysfunction [ 167 ]. Latest research [ 168–171 ] states that zinc supplementation also has a positive effect on the patients’ renal function, and low Zn levels in dialysis patients are independent predictors of mortality and infection-related hospitalization.…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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“…Recently, two meta-analyses including intervention studies conducted in both Western and non-Western countries revealed that Zn replacement results in the reduction in serum CRP levels, as well as MDA concentration, a serum oxidative stress marker [13,14]. More recently, it was demonstrated that Zn sulfate supplementation has favorable effects on CRP, fasting blood glucose, and renal function in Zn-deficient diabetic hemodialysis patients [15].…”

Section: Zinc Deficiency In Dialysis Patientsmentioning

confidence: 99%

“…A list of these trials is presented in Table 2 [3,[15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Zinc preparations such as zinc acetate (Novelzine ® ) and polaprezinc (Promax ® ) have been used for zinc supplementation.…”

Section: Treatment Of Zinc Deficiencymentioning

confidence: 99%

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Wakino

2023

Kidney and Dialysis

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Recently, as the number of elderly dialysis patients has been increasing, complications associated with low nutritional status such as infectious disease have had a strong influence on the prognosis of dialysis patients. Nutritional disorders are caused by the inadequate intake of the three major nutrients—proteins, fats, and carbohydrates—as well as vitamin and mineral deficiencies. Minerals are composed of various elements, including small-amount elements and trace elements, which are present in the human body in very small quantities lower than that of iron. In dialysis and predialysis patients, zinc, manganese, and selenium are the three major elements that are significantly depleted as compared to normal subjects; these deficiencies are sometimes symptomatic. Zinc deficiency is manifest as anemia, taste abnormality, and delayed wound healing, while selenium deficiency is associated with impaired cardiac function and immunocompromised condition. Zinc has multiple functions, since various enzymes, including DNA polymerase and RNA polymerase, need zinc as a cofactor, while selenium is a component of selenoproteins, including glutathione peroxidase and thioredoxin reductases, which are major antioxidative stress enzymes. These elements can only be supplemented exogenously and contribute to the sustainable QOL of dialysis patients. On the other hand, as regards other trace elements, including copper, chromium, manganese, lead, arsenic, etc., the association of their deficiency or intoxication with various involvements of dialysis patients were investigated, although all investigations were performed in cross-sectional studies or observational studies. Therefore, the supplementation of these elements is inconclusive, given the scarcity of other intervention studies. More conclusive studies are endorsed for the establishment of proper supplementation strategies.

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“…One trial had adolescent participants, while the other`s average ages were above 45-year-old. Four trials https://doi.org/10.1017/S0007114522002616 Published online by Cambridge University Press Accepted manuscript did not specify the type of diabetes in the inclusion criteria and patients had complications: diabetic foot ulcer (59) , diabetic hemodialysis with Zn-deficiency (56) , diabetic retinopathy (60) , and b-thalassemia major complicated (58) .…”

Section: Study Characteristicsmentioning

confidence: 99%

Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation

2022

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Although previous studies suggested the protective effect of zinc for type-2 diabetes (T2D), the unitary causal effect remains inconclusive. We investigated the causal effect of zinc as a single intervention on glycemic control for T2D, using a systematic review of RCTs and two-sample Mendelian randomization (MR). Four primary outcomes were identified: fasting blood glucose/fasting glucose, HbA1c, HOMA-IR, and serum insulin/fasting insulin level. In the systematic review, four databases were searched from the establishment to June 2021. Studies, in which participants had T2D and intervention did not comprise another co-supplement, were included. Results were synthesized through the random-effects meta-analysis. In the two-sample MR, we used random allocation of single nucleotide polymorphisms (SNPs), strongly related to zinc supplements, to infer the relationship causally, but not specified T2D. SNPs were from MR-base. In the systematic review and meta-analysis, 14 trials were included with a total of 897 participants. The zinc supplement led to a significant reduction in the post-trial mean of fasting blood glucose (mean difference (MD): -26.52 mg/dL, 95%CI: -35.13, -17.91), HbA1c (MD: -0.52%, 95%CI: -0.90, -0.13), and HOMA-IR (MD: -1.65, 95%CI: -2.62, -0.68), compared to the control group. In the two-sample MR, zinc supplement with 2 SNPs reduced the fasting glucose (inverse-variance weighted coefficient: -2.04 mmol/L, 95%CI: -3.26, -0.83). From systematic review and two-sample MR analyses, zinc supplementation alone may causally improve glycemic control among T2D patients. The findings are limited by power from the small number of studies and SNPs included in the systematic review and two-sample MR analysis respectively.

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The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract: The effects of zinc sulfate supplementation on serum copeptin, c-reactive protein and metabolic markers in zincdeficient diabetic patients on hemodialysis: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research.

Cited by 11 publications

References 42 publications

Progress in the study of nutritional status and selenium in dialysis patients

Progress in the study of nutritional status and selenium in dialysis patients

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation

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