Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women during reproductive age. Women with PCOS show raised Anti-Müllerian hormone (AMH) levels, due to increased number of small antral follicles and granulosa cells, and these may lead to anovulation. Measuring antral follicle count (AFC) and ovarian volume (OV) by ultrasound scanning gives insight to the ovarian function. This study is conducted to investigate the relation between AMH with AFC, OV and different biochemical parameters which determine PCOS. The study was carried out on thirty patients with PCOS as (group 1) compared with fifteen healthy women as control group (group 2). AMH, FBS, Insulin, HOMA/IR, Testosterone, cholesterol, Triglycerides (TG), body mass index (BMI) and hirsutism were measured for all women in both groups. The results revealed that the serum level of AMH is significantly higher in PCOS (11.90±4.23ng/ml) than control group (4.36±0.56ng/ml). As for AFC, there is high significant increase (26.10± 5.49 follicles) in PCOS group versus (9.07 ±1.83 follicles) in control group. Furthermore, the results revealed a highly significant difference in OV (11.20±2.78ml) in PCOS compared to (6.23±0.73ml) in control. There is a significant correlation between AMH, AFC and OV in PCOS. There is a high significant correlation between AMH, AFC, OV, BMI testosterone, HOMA/IR, HDL, cholesterol, and TG in both groups. It could be concluded that there is a tight positive correlation between AMH and AFC and OV.
V ITAMIN D is a prohormone nutrient, which is involved in skeletal and extraskeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. Iron deficiency anemia (IDA) is one of the most common diseases among pregnant women worldwide. Vitamin D deficiency (VDD) during pregnancy might be associated with some adverse effects on fetal growth. Thisstudy was designed to assess the possible relationship between IDA in pregnant mothers, their corresponding newborns and vitamin D deficiency (VDD). Research Design and Methods Maternal and fetal serum25-hydroxy vitamin D levels were evaluated using radioimmunoassay (RIA) technique, in 25 pregnancieswith IDA compared to 15 age-matched uncomplicated term gestations. Birth weight and clinical status of the neonateswere assessed.
Introduction: Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with a prevalence of 8-18% and implies various severe consequences to female health, including alarming rates of infertility, which accounts for approximately 75% of anovulatory infertility. Long non-coding RNA steroid receptor activator (lncRNA-SRA) affects multiple biological processes. However, it is not known whether lncRNA-SRA is associated with PCOS and the possible accompanied metabolic syndrome (MetS). Material and Methods: The expression levels of lncRNA-SRA were measured by real-time quantitative-PCR in PCOS patients (n=30 women), and in control group (n=20 women), patients with metabolic syndrome were diagnosed, and the association between lncRNA-SRA and metabolic syndrome parameters in PCOS group and control were analyzed. Results: LncRNA-SRA expression mean level was significantly higher in the women with PCOS than that in the control group. There was a high significant positive correlation between lncRNA-SRA expression and hirsutism, BMI, waist circumference (WC), and insulin levels, also with significant positive correlation between lncRNA-SRA with HOMA/IR and testosterone in PCOS group. Conclusion: The authors found that the lncRNA-SRA expression is potentially increased with PCOS and it has positive correlation with hirsutism, obesity, testosterone, and insulin resistance in PCOS. LncRNA-SRA is significantly increased in MetS subgroup of PCOS, thereby suggesting that elevated lncRNA-SRA might be an important mediator not only associated to hormonal and clinical parameters but also associates metabolic syndrome in PCOS and may be a mediator in the pathogenesis of both syndromes.
Purpose:To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and uterine Doppler ultrasonography for the prediction of severe preeclampsia (PE) and HELLP syndrome at the last trimester. Methods: Two groups were constructed; severe preeclampsia group consisted of 38 women; HELLP Syndrome group consisted of 12 women. Both groups were matched strictly for gestational age at last trimester. Maternal blood sample for PAPP-A was collected and uterine Doppler ultrasonography was performed as soon as any woman under the study was diagnosed as severe preeclampsia or HELLP syndrome at last trimester and compared. Results: Mean ages of participants, Parity, gestational weeks and fetal weights were similar. Mean PAPP-A levels were significantly higher in severe preeclampsia and HELLP groups. There was a statistically significant difference regarding Resistive Index (RI) (P<0.001) and Pulsatility Index (PI) (P=0.005) between cases presenting with severe preeclampsia and HELLP groups. Conclusion: PAPP-A levels could provide prediction for severe preeclampsia and HELLP syndrome at last trimester. Increased uterine artery resistance in the third trimester of pregnancy could be used to predict maternal complications including severe preeclampsia and HELLP syndrome.
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