Relation between Anti-Müllerian Hormone with Antral Follicle Count and Ovarian Volume in Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women during reproductive age. Women with PCOS show raised Anti-Müllerian hormone (AMH) levels, due to increased number of small antral follicles and granulosa cells, and these may lead to anovulation. Measuring antral follicle count (AFC) and ovarian volume (OV) by ultrasound scanning gives insight to the ovarian function. This study is conducted to investigate the relation between AMH with AFC, OV and different biochemical parameters which determine PCOS. The study was carried out on thirty patients with PCOS as (group 1) compared with fifteen healthy women as control group (group 2). AMH, FBS, Insulin, HOMA/IR, Testosterone, cholesterol, Triglycerides (TG), body mass index (BMI) and hirsutism were measured for all women in both groups. The results revealed that the serum level of AMH is significantly higher in PCOS (11.90±4.23ng/ml) than control group (4.36±0.56ng/ml). As for AFC, there is high significant increase (26.10± 5.49 follicles) in PCOS group versus (9.07 ±1.83 follicles) in control group. Furthermore, the results revealed a highly significant difference in OV (11.20±2.78ml) in PCOS compared to (6.23±0.73ml) in control. There is a significant correlation between AMH, AFC and OV in PCOS. There is a high significant correlation between AMH, AFC, OV, BMI testosterone, HOMA/IR, HDL, cholesterol, and TG in both groups. It could be concluded that there is a tight positive correlation between AMH and AFC and OV.

A Cross-Sectional Study on Potential Ovarian Volume and Related Factors in Women with Polycystic Ovary Syndrome from Infertile Couples

“…7 Therefore, OV is still a potential diagnostic tool for detecting PCOS. Several studies have investigated the relationship between OV and PCOS, 8 obesity, 9 insulin resistance, 10 androgen activity, 11,12 metabolic syndrome, 13 and AMH levels 12,14,15 in PCOS patients. Furthermore, to date, while an ovarian volume of >10mL is a part of the Rotterdam criteria for PCOS, several research groups have suggested various cut-off points for OV due to variation in population characteristics.…”

Correlation between Anti-Mullerian Hormone Levels and Antral Follicle Numbers in Polycystic Ovary and Metabolic Syndromes

“…Normally, hirsutism is characterized as mild within scores up to 15, moderate from 16-25, and severe above 25. Biochemical HA was determined at the serum testosterone level >2.5 nmol/L [14]. The selection of the control group was carried out using the ultrasound method.…”

“…Subjects who have undergone previous ovarian surgery, received cytotoxic drugs or pelvic irradiation, who undergone 3 months of hormone therapy before the study, or had another endocrinological disorder were excluded. The diagnosis of PCOS was based on two of three Rotterdam criteria: (1) irregular menstrual cycles or OA (≥35 days); (2) HA, clinical (the acne presence of acne, or hirsutism) or biochemical manifestations (increase in the level of at least one circulating ovarian androgen); and (3) polycystic ovaries (PCOs) on ultrasound [14].…”