These results suggest that ICAM-1 has a diagnostic value in patients with BA and would be a promising helpful tool when investigating patients with NC.

ABSTRAKFaid-Allah E, Ghoneim E, Ibrahim AHM. 2016. Estimasi komponen varian dan nilai pemuliaan kriteria pertumbuhan pra-sapih pada domba Romney. JITV 21(2): 73-82. DOI: http://dx.doi.org/10. 14334/jitv.v21i2.1353 Penelitian ini dilakukan untuk melihat komponen-komponen ragam, pengaruh genetik langsung, parameter genetik maternal, estimasi nilai pemuliaan (EBV) dan faktor-faktor yang mempengaruhi kriteria pertumbuhan pra-sapih pada domba Romney.

Obstructive jaundice in a rat model predisposes to bacterial translocation. This suggests a mechanism whereby jaundiced patients are susceptible to septic complication.

Serum complement C4a did not correlate with any of transaminases, HCV viremia or with the histopathological scores. Although C4a decreased with higher stages of fibrosis, this change was not significant enough to predict individual stages of fibrosis. Yet, it could predict significant fibrosis with acceptable clinical performance.

This study investigates genetic diversity and structure of native Egyptian cattle populations, called Baladi, as Saidi from Southern Egypt, Menufi from Mid-Delta and their F1 crosses with the French Tarentaise breed using DNA Microsatellite markers. A total of unrelated 97 individuals were genotyped utilizing eight SSR primers (ETH10, ETH225, BM1818, BM1824, BM2113, SPS115, TGLA53 and TGLA126). All utilized SSR were found to be polymorphic. The highest and lowest numbers of alleles detected were 16 and 6 at TGLA53 and SPS115 loci, respectively. Baladi-Tarentaise crosses (Bal-Tar) had the highest number of alleles over all. The PIC values of 7 loci were higher than 0.5, indicating high allelic variation of utilized markers. Estimated PIC values were up to 0.898, 0.866 and 0.873 for TGLA53 genotyped in Saidi, Menufi and Bal-Tar, respectively. Hobs values were lower than the expected ones in the native populations accompanied with positive values for Fis and significant deviation from HWE indicating inbreeding trend in native populations. Structure analysis indicated three ancestral genetic backgrounds. The native populations share two main backgrounds in almost equal percentages, while the Bal-Tar had the third one. The three populations showed low percentage of admixture. The studied Mediterranean cattle populations that belong to Egypt and France seem to have differentiated from each other with only little genetic exchange between the geographically isolated populations so local cattle is very similar.

The objective of this study was to test the association of variation in a 356 bp region in exon 1 of the caprine leptin gene with milk production traits (milk yield (MY), milk fat content (FAT), milk protein content (PRO), milk lactose content (LAC), milk solid not fat content (SNF), pH and somatic cell count (SCC)) in 106 Barki does using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). General linear model was used to test association between the variation in leptin and milk-production traits. The SSCP banding patterns for leptin revealed two variants (L1 and L2), which contained two nucleotide sequence difference (c.670528A/G and c.670639T/C). The c. 670528A/G substitution results in the substitution of valine with alanine and c.670639T/C results in the substitution of arginine with histidine. Association analysis between the variation in leptin with milk production traits revealed that leptin genotype was associated (P < 0.05) with PRO and highly (P < 0.001) associated with MY. The presence of the L1 variant in the doe genotype was significantly associated with lower MY (P < 0.01) and decreased PRO (P < 0.01), whereas, the presence of the L2 variant in the doe genotype was significantly associated with higher MY (P < 0.05). The detected leptin variants showed significant (P < 0.05) additive effect on pH and highly significant (P < 0.01) dominance effects on MY and PRO. This suggests that selection for the leptin genotypes might increase milk production and milk protein content in Barki goats.

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