A deep eutectic solvent (DES) and polyethylene glycol (PEG), promoted the environmentally friendly and fast synthesis of dithiocarbamate derivatives via a one-pot, three-component condensation of an amine, carbon disulfide, and a variety of electrophilic reagents in high yields and short reaction times without organic solvents and tedious work-up. These green solvents can be recovered and recycled for subsequent reactions.
A Highly Efficient Synthesis of Dithiocarbamates in Green Reaction Media. -Three-component condensation of epoxides, alkyl halides or α,β-unsaturated carbonyl compounds with amines and carbon disulfide produces dithiocarbamates in good to excellent yields. All reactions can be carried out in polyethylene glycol or in deep eutectic solvent composed of urea and choline chloride. Both types of solvents can be recovered and reused. -(AZIZI*, N.; GHOLIBEGLO, E.; RSC Adv. 2 (2012) 19, 7413-7416, http://dx.doi.org/10.1039/c2ra20615c ; Chem. Chem. Eng. Res. Cent., Tehran, Iran; Eng.) -Mais 08-044
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